摘要
目的:探讨血运重建对急性心肌梗死(AMI)患者心脏胶原合成和降解代谢的影响。方法:对65例AMI患者分别予以常规强化内科保守治疗(常规治疗组,20例)或在此基础上的血运重建治疗(血运重建组,45例),应用酶联免疫法分别检测AMI后1周、3个月及6个月的血清Ⅰ型前胶原羟基端肽(PⅠCP)、Ⅲ型前胶原(PCⅢ)、基质金属蛋白酶-1(MMP-1)及基质金属蛋白酶组织抑制剂因子-1(TIMP-1)含量,并计算PⅠCP/PCⅢ的比值。以48例正常人为对照组。结果:与对照组比较,常规治疗组各亚组和血运重建组6个月亚组的PⅠCP及常规治疗组和血运重建组各亚组的PCⅢ明显增高(P<0.05),而2组的PⅠCP/PCⅢ、MMP-1及TIMP-1显著降低(P<0.05)。血运重建组各亚组的PⅠCP、1周亚组的PCⅢ及6个月亚组的MMP-1低于常规治疗组相应时点亚组(P<0.05)。结论:AMI后出现心脏胶原重塑的表现。在常规治疗的基础上,血运重建可进一步抑制AMI后心脏胶原的合成与降解。
Objective：To investigate the effects of revascularization on myocardial collagen remodeling in patients with acute myocardial infarction （AMI）. Method： According to the different therapies, sixty-five patients with AMI were divided into conventional therapy group （n=20） and revascularization group （n=45）. Enzymelinked immunosorbent assay was employed to detect serum level of carboxy-terminal propeptide of procollagen type Ⅰ （PI CP）, precollagen type Ⅲ （PCⅢ）, matrix metalloproteinase-1 （MMP-1） and tissue inhibitor-1 （TIMP-1） at the 1st week, the 3rd month and the 6th month after AMI. Forty-eight healthy persons served as normal control. Result：Compared with the control group, serum concentration of PⅠCP in conventional therapy group at all time points after AMI and revascularization group at the 6 th month were increased, so did serum concentration of PCⅢ in both group. AMI patients exhibited significantly higher PⅠCP/PC Ⅲ and serum levels of MMP-1 and TIMP-1 as compared with those of healthy persons. Serum concentration of PⅠCP at all times, PCⅢ at the 1st week and MMP-1 at 6th month after AMI were significantly lower in revascularization group than those in conventional therapy group respectively. Conclusion.. Myocardial collagen remodeling occurs after AMI. Based on conventional therapy, revascularization may further inhibit the synthesis and degradation of the myocardial collagens in patients with AMI.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2008年第5期369-372,共4页
Journal of Clinical Cardiology
基金
贵州省科学技术基金资助项目[黔基合计字No:(2003)3043]
贵州省高层次人才科研条件特助经费项目[黔人领函No:(2005)14]
关键词
心肌梗死
血运重建
胶原
重塑
Myocardial infarction
Revascularization
Collagen
Remodeling
