摘要
目的:探讨阿托伐他汀对自发性高血压大鼠心肌组织PPARs(peroxisome proliferator-activated re-ceptors,PPARs)表达的影响及其对心肌肥厚的逆转作用与可能机制。方法:自发性高血压大鼠分为阿托伐他汀灌胃治疗组(SHR-A,30mg.kg-1.d-1)及模型组(SHR),治疗8周,同周龄Wistar-Kyoto鼠为正常血压对照组。治疗前及治疗后2、4、8周测量大鼠尾动脉血压。治疗后测血浆血脂水平,以心脏组织病理分析判断心肌肥厚,Western blotting检测心肌组织PPARα、PPARγ的表达水平。结果:经过8周治疗,SHR-A组及SHR组血压及血脂水平无明显差异(P>0.05)。SHR-A组左室重量指数低于SHR组(P<0.01)。在SHR-A组,PPARα及PPARγ表达高于SHR组(P<0.01)。结论:阿托伐他汀显著改善自发性高血压大鼠心肌组织PPARs表达,有效逆转左室肥厚,可能与其降压及降脂作用无关。
AIM： To investigate the effects of atorvastatin on myocardium peroxisome proliferator- activated receptors （PPARs） expression, regression of left ventricular hypertrophy, and the possible mechanisms in spontaneously hypertensive rats （SHR）. METHODS： 16 nine -week-old male spontaneously hypertensive rats were randomly divided into two groups： SHR received atorvastatin at dose of 30 mg·kg^-1·d^-1 by oral gavage once daily for 8 weeks （ SHR - A, n = 8）, and SHR received vehicle （0.9% saline） as controls （SHR, n = 8）. Age -matched Wistar- kyoto rats received vehicle for 8 weeks were served as normaltensive controls （ WKY, n = 8）. Systolic blood pressure was measured at the beginning, 2, 4 and 8 weeks of the experiment. At the end of the experiment, plasma lipid levels were measured. Left ventricular hypertrophy was accessed by pathological analysis. The expressions of PPARa and PPARγ/were investigated by the method of Western blotting. RESULTS： There was not much difference of systolic blood pressure and plasma lipid levels between SHR - A and SHR group （ P 〉 0. 05 ）. Compared with SHR group, left ventricular weight mass index decreased significantly in SHR- A group （P 〈0. 01 ）. The myocardium PPARa and PPARγ/expression increased significantly （P 〈 0. 01 ）. CONCLUSION： Atorvastatin regresses left ventricular hypertrophy and increases myocardium PPARa and PPARγ/ expression in spontaneously hypertensive rats, which is independent of its lipid-lowering activity.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2008年第6期1069-1073,共5页
Chinese Journal of Pathophysiology
基金
浙江省科技厅研究基金资助项目(No021107613)
关键词
阿托伐他汀
肥大
左心室
过氧化酶体激增剂活化受体
Atorvastatin
Hypertrophy, left ventricular
Peroxisome proliferator-activated peceptor
