摘要
可降解骨组织工程复合支架材料可以分为同类生物材料的复合,不同类别生物材料之间的交叉复合。天然材料存在性能难以重现,难以大批量生产,在体内水解过程中不能保持空间构型等缺点;人工合成生物高分子材料之间的复合,但其本体降解特性会使支架过早丧失结构完整性,且局部形成降解产物的积累,引起炎症反应;人工合成无机材料之间的复合,存在脆性大、润湿性较差,降解性能较差等不足。交叉复合可以克服单种材料支架的缺陷。交叉复合材料可以分为:天然生物材料与无机材料之间的复合;人工合成高分子与无机材料之间的复合;金属基交叉复合材料。
The biodegradable composite scaffold materials for bone tissue engineering include compounds of the same sort of materials as well as cross compound of different sorts of materials. Composites formed by nature materials have problems in quantity production and holding the structure during hydrolization; Artificial biopolymers composites may cause inflammatory reaction due to the degradation production accumulated in local site. Bulk degradation results in premature lose of structure integrality; Artificial inorganic compound materials are brittle, with bad wettability and degradation property. Scaffolds cross can overcome the shortcomings above and meet the requirement of tissue engineering. Cross composite materials consist of composite materials made of natural biomaterials and inorganic materials, composite materials made of artificial biopolymers and inorganic materials, and composite materials made of metal and other materials.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第19期3689-3692,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金资助项目(30772182)“可降解金属镁合金与成骨细胞的分子相容性”~~
