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2006年全国自身抗体检测质量控制总结 被引量:8

Summary of the nation-wide autoantibodies test quality survey in 2006
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摘要 目的 了解我国自身抗体检测的现状,促进自身抗体检测水平的提高。方法 以自愿报名的方法确定参与单位。质量控制项目包括抗核抗体(ANA)、抗双链DNA(dsDNA)抗体)、抗可提取核抗原(ENA)抗体、抗线粒体抗体(AMA),抗平滑肌抗体(ASMA)、抗环瓜氨酸肽抗体(抗CCP)5项,共15份标本。标本发放及结果分析采用双盲操作。结果 共55家医院,科室参加质量控制活动。本次ANA、抗dsDNA抗体、AMA/ASMA和CCP的正确率分别为92%、89%、96%、72%,抗ENA按抗RNP、Sm、SSA、SSB和Scl-70分别分析,正确率分别为98%、89%、92%、75%、77%。结论 我国自身抗体检测情况与前3次质控相比,检测的项目逐年增多,检测水平逐步提高。 Objective To consecutively understand the current national clinical testing quality and enforce quality-control of auto-antibody detection. Methods Hospitals or departments were recruited by letters or telephone communications. The autoantibodies examined for quality control survey included antinuclear antibodies (ANA), anti-double-stranded DNA (A-dsDNA) antibody, anti-extractable nuclear antigens (A-ENA) antobodies, anti-mitochondria antibody (AMA)/anti-smooth muscle antibody (ASMA), and anti-CCP antibody. Each autoantibody was tested in 3 samples, and altogether 15 samples in total for testing. Sample designation and testing results data analysis were double-blinded. Results Fifty-five hospitals/departments participated in this survey. The accuracy rates for this survey were 92%, 89%, 96%, 72% respectively for ANA, A-dsDNA, AMA/ASMA, and anti-CCP. Anti-ENAs were further divided into anti- . RNP, Sm, SSA, SSB and Scl-70 subgroups, and the accuracy rates were 98%, 89%, 92%, 75% and 77% respectively. Conclusion Compared to the previous 3 national surveys, accuracy rates in our country's autoantibody testing is increaseing steadly with more testing items included each year. This indicats that the quality of auto-antibody testing is improving across the country.
出处 《中华风湿病学杂志》 CAS CSCD 2008年第6期382-385,共4页 Chinese Journal of Rheumatology
关键词 自身抗体 免疫学试验 质量控制 Autoantibodies Immunologic tests Quality control
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  • 2邓学新,唐福林.48家医院自身抗体检测的质控总结[J].中华风湿病学杂志,2004,8(7):387-390. 被引量:17
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