摘要
目的探讨幽门螺杆菌（Hp）感染对过敏性紫癜（HSP）患儿肾损害的影响。方法采用13C尿素呼气试验（13C-UBT）方法将2002年1月-2005年12月广州市儿童医院收治的HSP患儿304例（其中男176例,女128例;年龄3-14岁）分为Hp感染（A组）91例,无Hp感染（B组）213例,采用χ^2验比较二组间肾损害发生率;对HSP伴Hp感染患儿,进行驱Hp治疗,予2周的三联疗法：奥美拉唑（7岁及以下10mg/d,7岁以上15mg/d）分2次口服。克拉霉素片15mg/（kg·d）,分2次口服。A组中有肾损害60例,经治疗Hp转阴45例（C组）,未转阴15例（D组）,采用χ^2验,比较C、D二组间肾损害恢复情况。结果A组肾损害的发生率为65.9%（60/91例）,B组为35.2%（75/213例）,二组比较有显著性差异（χ^2＝24.378P〈0.01）。C组肾损害完全恢复38例将恢复率为84.4%,D组肾损害完全恢复7例,恢复率为46.7%。二者比较有显著性差异（χ^2＝8.563P〈0.01）。结论Hp感染对HSP患儿肾损害的发生有明显的影响,及时发现和处理Hp感染有助于患儿肾损害的恢复。
Objective To evaluate the relationship between Henoch - Schonlein purpura （HSP） accompanying renal impairment and helicobater pylori （Hp） infection. Methods This study consisted of 304 patients with HSP. The patients were divided into 2 groups（ group A and group B） based on Hp infection or not（91 cases in group A and 213 cases in group B）. Compared with the rates of accompanying renal impairment in 2 groups. And observed the recovery from renal impairment between the patients who were turned into negative （ group C ） and patients still were positive after the anti - Hp therapy（ group D）. Numeration data were analyzed by χ^2 test. Results Group A which was with Hp infected,the accompanying renal impairment ratio was 65.9%. Group B which was without Hp infected,the ratio was 35.2%. There was significant difference between 2 groups （ χ^2 = 24. 378 P 〈 0.01 ）. In group A ,60 patients who were HSP accompanying renal impairment with Hp infection, after anti -Hp therapy ,45 patients were negative in Hp infection（ group C）, and 84.4% recover from renal impairment, but 15 were still positive （ group D） and only 46.7% recover. The ratio of group C was higher than the group D （ χ^2 = 8. 563 P 〈 0.01 ）. Conclusions Our study shows a significant correlation between Hp infection and renal impairment in HSP patients. And the treatment of anti - Hp in time may be helpful for the recovery from renal impairment in the HSP.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第9期684-685,共2页
Journal of Applied Clinical Pediatrics
关键词
紫癜
过敏性
幽门螺杆菌感染
肾损害
Henoch - Schonlein purpura
helicobater pylori infection
renal impairment
