摘要
目的评价血清肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、M2-丙酮酸激酶(M2-PK)和胃蛋白酶原Ⅰ(PGⅠ)联合检测对胃癌诊断的价值。方法采用酶联免疫法测定69例胃癌患者、40例良性胃病患者以及30例健康人血清中CEA、CA19-9、CA125、M2-PK和PGⅠ的水平,比较3组间的差异。结果胃癌组患者血清中CEA、CA19-9、CA125、M2-PK和PGⅠ的阳性率均显著高于良性胃病组及对照组(P<0.01)。5项标志物联合检测的敏感性为80.1%,与单项检测相比差异有显著性(P<0.01)。结论CEA、CA125、CA19-9、M2-PK和PGⅠ对胃癌具有较高的辅助诊断价值,5项标志物联合检测有助于提高胃癌诊断的敏感性。
Objective To evaluate the diagnostic value of combined detection with CEA, CA19-9, CA125, M2-PK and PG Ⅰfor gastric cancer. Methods The serum CEA, CA19-9, CA125, M2-PK and PG Ⅰ levels in 69 patients with gastric cancer, 40 patients with benign gastric diseases and 30 healthy controls were measured with EL ISA method. Results The positive rate of CEA, CA19-9, CA125, M2- PK and PG Ⅰ in patients with gastric cancer were obviously higher than those in the group with benign gastric diseases and in the control group （ P 〈 0.01 ）. Moreover, the sensitivity of the combined detections including the five tumor markers were higher than those of the respective. Conclusion The serum CEA, CA19-9, CA125, M2-PK and PG Ⅰ levels are very valuable in diagnosis of gastric cancer. The combined detection five tumor markers can promote the sensitivity for the diagnosis of gastric cancer
出处
《中国实验诊断学》
2008年第6期737-739,共3页
Chinese Journal of Laboratory Diagnosis
