摘要
以阿霉素为模型药物,采用薄膜分散-pH梯度法制备羧甲基壳聚糖修饰的纳米脂质体,并研究了该纳米脂质体的包封率、形态、粒径、稳定性和pH敏感性。结果表明:羧甲基壳聚糖修饰后阿霉素脂质体的ζ电位、酸性条件下药物渗漏速率、渗漏百分率比未修饰的阿霉素脂质体均有明显提高。所制pH敏感阿霉素纳米脂质体包封率达87%左右,体积粒径为(74.7±11.5)nm;4℃冷藏保存3个月稳定性良好。
The film-pH gradient method was used to prepare carboxymethyl chitosan （CMCT） modified pH-sensitive nanoliposomes by using doxorubicin （DXR） as a model drug. The encapsulation efficiency, morphology, particle size distribution, stability and pH-sensitivity of the pH-sensitive nanoliposomes were investigated. The results show that the ζ potential, the rate and percent of drug release in acidic condition of the nanoliposomes all increased significantly after modification and better pH-sensitivity can be gained. The encapsulation efficiency of the pH-sensitive DXR nanoliposomes can reach about 87 %. They are spherical with particle size distribution of （74.7±11.5） nm, which remain quite stable conserved in refrigerator at 4 ℃ for 3 months.
出处
《华东理工大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2008年第3期364-368,共5页
Journal of East China University of Science and Technology
基金
上海市重点学科建设项目
上海市纳米科技专项(0652nm027)资助
