摘要
目的:探讨乳癌组织中细胞周期素G(Cyclin G)的表达及临床意义。方法:应用免疫组织化学SP法检测88例乳癌组织及40例非癌区乳腺组织中Cyclin G的表达情况,并分析其与相关临床病理指标的关系。结果:乳癌组织和非癌区乳腺组织中Cyclin G的阳性表达率分别为38.6%、2.5%,差异有统计学意义(P<0.05)。乳癌组织中Cyclin G的过表达与肿瘤大小、组织学分级及P53的表达无关,而与淋巴结转移、绝经状态、激素受体有关(P<0.05)。结论:Cyclin G的异常表达可能与乳癌的发生、发展有关,可作为判断乳癌淋巴结转移倾向的参考指标。
Aim：To investigate the expression of Cyclin G in breast cancer and its clinical significance. Methods：The expression of Cyclin G was detected by immunohistochemical SP method in 88 cases of breast cancer tissue and 40 cases of adjacent normal breast tissue ,and its correlation with the clinical-pathological features was analyzed. Results ：The positive rate of Cyclin G was 38.6% in breast cancer tissue and 2.5% in adjacent normal breast tissue,and there was significant difference between the two groups（ P 〈 0.05 ）. The over-expression of Cyclin G was not correlated with tumor size, histological grade and expression of P53 （P 〉 0.05 ） in breast cancer tissue,but correlated with lymph node metastasis, menopausal status and hormone receptor status （ P 〈 0.05 ）. Conclusion ： The over-expression of Cyclin G is probably correlated with the occurrence and development of breast cancer,and it can be servea as an index for the tendency of lymph node metastasis of breast cancer.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第3期506-509,共4页
Journal of Zhengzhou University(Medical Sciences)
