摘要
目的探讨大肠癌手术前后肠道粘膜免疫功能的变化,评估常规大肠癌手术对患者肠道粘膜免疫功能的影响,了解术后使用肠道益生菌制剂治疗肠道粘膜免疫功能紊乱的疗效。方法将大肠癌患者随机分为两组(实验组和对照组)。对照组:患者常规实施大肠癌根治术;实验组:患者常规实施大肠癌根治术,并于手术后可以进食起开始补充肠道益生菌制剂。两组均于术前,术后第一次排便,排便后5天,术后1月,4次抽静脉血检测血清CRP及TNF-α的含量,同时留取粪便检测分泌型免疫球蛋白(SIgA)含量。结果①两组患者术后第一次粪便SIgA含量与术前相比均明显减少(P<0.05),术后第二次粪便SIgA含量较术后第一次并未明显增多(P>0.05),实验组术后1月粪便SIgA含量较术后第一、二次明显升高,且明显高于对照组(P<0.05);②两组患者术后第一次血清TNF-α含量较术前明显升高(P<0.05),术后第二次较术后第一次血清TNF-α含量有所降低(P<0.05),术后第三次血清TNF-α含量实验组较对照组明显降低(P<0.05);③两组患者血清CRP术后第一次较术前均明显升高(P<0.05),术后第二次较第一次明显降低(P<0.05),术后第三次较第二次也明显降低(P<0.05),但实验组与对照组比较,实验组降低更明显(P<0.05)。结论①大肠癌患者手术后肠道粘膜免疫功能明显降低。②大肠癌患者术后粪便SIgA水平下降,应用肠道益生菌制剂短期内对升高SIgA效果不明显,但长期应用可显著升高SIgA水平。③大肠癌患者术后血清TNF-α和CRP水平显著升高,应用肠道益生菌制剂后可显著降低。
Objective To investigate the intestinal mucosal immune function changes before and after colorectal cancer surgery, assess conventional surgery for colon cancer patients with intestinal mucosal immune function, after understanding the use of probiotics in the treatment of intestinal mucosa intestinal disorder of the immune function efficacy. Methods Colorectal cancer patients were randomly divided into two groups （the experimental group and control group）. Control group： conventional implementation of colorectal cancer in patients with radical surgery; Experimental groups： conventional implementation of colorectal cancer in patients with radical surgery, and can eat after the operation started to add probiotic intestinal preparations. Both groups were in operation before and after the first defecation, five days after defecation, after one month, four pumping blood serum CRP and TNF-α content, while collecting stool test SIgA content. Results ①The first two groups of patients with fecal content of SIgA were significantly reduced compared to the former （P〈0.05）, after the second time in more SlgA stool after the first had not increased significantly （P〉0.05）. After the experimental group than in one month SIgA stool after the first, second significantly increased, and significantly higher （P〈0.05）. ②The first two groups of patients with serum TNF-α in significantly higher than the preoperative （P〈0.05）, after a second after the first serum TNF-α in a decrease （P〈0.05）. After the third serum TNF-α in the experimental group than the control group was significantly lower （P〈0.05）.③CRP in patients with the two groups after the first of the former were more significantly higher （P〈0.05）, after the second time than the first time decreased significantly （P〈0.05）, after the third time in the second, it was obvious lower （P〈0.05）, but the experimental group compared with the control group, more significantly reduce the experimental group （P〈0.05）. Conclusion ①Patients with colorectal cancer surgery after intestinal mucosal immune function decreased significantly. ②Colorectal cancer patients with faecal SIgA levels drop, intestinal probiotics preparation of short-term effects of higher SIgA not obvious, but long-term use can be significantly increased levels of SIgA. ③Colorectal cancer patients with serum TNF-α and CRP levels were significantly higher, after the preparation of intestinal probiotics can be significantly reduced.
出处
《中国现代医药杂志》
2008年第6期20-24,共5页
Modern Medicine Journal of China
关键词
大肠癌
肠道粘膜免疫
分泌型免疫球蛋白A
肿瘤坏死因子
C反应蛋白
益生菌
Colorectal Cancer Intestinal mucosal immunity Secretory immunoglobulin A Tumor necrosis factor C-reactive protein Probiotics
