摘要
目的探讨细胞因子在抑郁症自杀未遂患者发病中的作用。方法对44例抑郁症自杀未遂患者在抗抑郁治疗前后分别进行HAMD评分,采用酶联免疫吸附法检测IL-2、IL-6,并以30例健康者作对照。结果抑郁症自杀未遂患者组治疗前IL-2、IL-6水平明显高于对照组(P<0.05),经6周治疗后,IL-2水平明显下降,IL-6水平有增高趋势(P>0.05)。结论IL-2可能在抑郁症自杀的发病中起一定作用。IL-6的水平可作为抑郁症自杀的一个特征性标志。
Objective To explore the role of cytokine on suicide behavior of depressive patients with incomplete suicide. Methods A total 44 depressive patients with incomplete suicide were assessed by Hamilton Depression Rating Scale （HAMD） and IL-2, IL-6 were detected by ELISA before and after treatment. Thirty healthy persons were in control group. Results Before treatment,concentrations of IL-2 and IL-6 in depressive patients with incomplete suicide were significantly higher than 1hose in control group（p〈0.05）. IL-2 concentration decreased notably, but IL-6 concentration trended to heighten（P〉0.05）after 6-week treatment. Conclusion with IL-2 might play a role in the pathogenesis of suicide and IL-6 could act as a mark of suicide in patients depression.
出处
《精神医学杂志》
2008年第3期197-198,共2页
Journal of Psychiatry
关键词
抑郁症
自杀未遂
细胞因子
Depression Incomplete suicide Cytokine
