摘要
目的:探讨肝再生磷酸酶-3(PRL-3)与RhoC的表达与结、直肠癌浸润转移的关系及其相关性。方法:采用免疫组化法检测48例结、直肠癌组织中PRL-3和RhoC的表达情况,结合临床病理学资料,分析其与结直肠癌浸润转移的关系及其相关性。结果:结、直肠癌中RhoC、PRL-3蛋白阳性表达率分别为64.58%(31/48)和68.75%(33/48),二者的表达与结、直肠癌的浸润深度、临床分期和有无淋巴结转移相关,而与病人的年龄、性别、肿瘤细胞分化程度无相关性。在结、直肠癌中PRL-3、RhoC蛋白的表达具有密切相关性。结论:结、直肠癌中PRL-3、RhoC蛋白的表达与其浸润转移密切相关,联合检测这两个指标对了解结、直肠癌的生物学行为和判断预后具有一定的价值。
Objective：To investigate the expression of PRL--3 and RhoC proteins and its correlation to invasion and metastasis of colorectal carcinoma. Methods：Immunohistochemical staining was used to detect the expression of PRL--3 and RhoC and analyze its relation to invasion and metastasis in 48 cases of colorectal carcinoma. Results： The positive rates of PRI.--3 and RhoC expression were 56.25% and 52. 08%, respectively,and were closely correlated to invasion depth, clinical stage and lymphatic metastasis （P 〈0. 05）, but not correlated with tumor differentiation and the age and sex of patients （P 〉 0.05） . Conclusion： The expression of PRL- 3 and RhoC is closely correlated to invasion and metastasis of colorectal carcinoma. Combined detection of the expression of PRL-3 and RhoC may provide some value to the biological behavior of colorectal carcinoma and to the prognosis of patients.
出处
《黑龙江医药科学》
2008年第3期14-15,16,共3页
Heilongjiang Medicine and Pharmacy
