摘要
目的：观察泮托拉唑治疗上？肖化道出血的临床疗效及安全性。方法：对临床证实142例上消化道出血患者随机双盲分为试验组（70例）和对照组（72例），分别用泮托拉唑和奥美拉唑40mg，iv，bid，疗程3—5d；观察两组给药后72h及120h的临床症状改善，实验室指标或内镜下止血征象。结果：总有效率试验组100．O％，对照组98．6％，两组比较差异无显著性（P〉0．05）。无明显不良反应发生。结论：注射用泮托拉唑治疗上消化道出血疗效显著，无明显毒副反应。
OBJECTIVE To research the clinical effect and safety of pantoprazole in the treatment of upper gastrointestinal bleed- ing. METHODS 142 patients with upper gastrointestinal bleeding were randomly divided into 2 groups ,72 cases in the control group were given omeprazole for 40 mg（ iv, bid, 3 to5 days） ;70 cases in the treating group were given pantoprazole for 40 mg（ iv, bid, 3 to5 days）. They were observed the clinical symptomatic amelioration after 72 h and 120 h and laboratory index or hemostasis sign under the endoscope. RESULTS After treatment, the total efficiency rate in treating group were 100% , control group 98.6%. There was no significant difference between two groups （ P 〉 0.05 ）. The biochemical indicator of two groups had no changes after treatment. And patients of two groups were obviously occurred adverse effect of drug. CONCLUSION Pantoprazole is an effective drug for treatment of upper gastrointestinal bleeding with fewer side effects.
出处
《天津药学》
2008年第3期38-39,共2页
Tianjin Pharmacy
关键词
泮托拉唑
上消化道出血
pantoprazole upper gastrointestinal bleeding
