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抑癌基因RUNX3与肿瘤相关性的研究进展

Study Progress on Relation of Tumor-suppressing Gene RUNX3 and Tomors
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摘要 RUNX3基因是一种肿瘤抑制基因,是RUNX转录因子的家族成员,可能以调节因子的身份参与转化生长因子β介导的信号转导通路。其表达下调在多种恶性肿瘤的发生、发展中起重要作用,失活的主要机制是启动子的高甲基化和杂合性缺失,尤其启动子区CpG岛的甲基化在肿瘤中的作用,更是学者们关注的焦点。 RUNX3,a kind of tumor-suppressing gene, is a member of RUNX transcription factor family. It can take part in the transforming growth factorβpathway as a regulatory factor. And it＇s down regulatory expression plays an important role in several malignant tumors, the main mechanisms of which are hypsomethylation and loss of hetemzygosity（LOH） of the promoter, especially the effect of methylation of CpG insular of the promoter region ,which has drawn many scholars＇ interest.
作者 张勇 秦娜
机构地区 广西医科大学第一附属医院放疗科
出处 《医学综述》 2008年第13期1973-1975,共3页 Medical Recapitulate
关键词 RUNX3 基因 甲基化 失活 肿瘤 RUNX3 Gene Methylation Deactivation Tumor
分类号 R730.231 [医药卫生—肿瘤]
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参考文献22

  • 1Kato N, Tamura G, Fukase M, et al. Hypennethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants[ J ]. Am J Pathol,2003,163(2) :387-391.
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  • 5Li QL,ho K,Sakaura C ,et al. Causal relationship between the loss of RUNX3 expression and gastric cancer [J]. Cell,2002,109 ( 1 ) : 113-124.
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  • 7Sakakura C, Hasegawa K, Miyagawa K, et al. Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancem [ J]. Clin Cancer Res,2005,11 (18) :6479.
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  • 9Homma N, Tamura G, Honda T, et al. Spreading of methylation within Runx3 CpG island in gastric cancer[J]. Cancer Sci,2006, 97( 1 ) :51-56.
  • 10Wei D,Gong W, Oh SC,et al. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis [J]. Cancer Res ,2005,65 ( 11 ) :4809-4816.

二级参考文献28

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  • 9Kato N, Tamura G, Fukase M, et al. Hypermethylation of the runx3 gene promoter in testicular yolk sac tumor of infants. Am J Pathol,2003,163:387-391.
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医学综述
2008年 第13期

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