摘要
目的研究酸枣仁水煎液对大鼠睡眠时相的影响。方法采用多导睡眠图描记方法,以脑电图(EEG)、肌电图(EMG)不同变化为睡眠分期的区分指标来分析酸枣仁水煎液对大鼠睡眠时相的影响。结果按17.5 g/kg(生药量)的剂量,给予实验动物灌胃7d后能延长自由活动大鼠总的睡眠时间,在睡眠时相上主要表现为延长SWS2,对SW S1和REMS没有明显的影响。结论酸枣仁水煎液可使大鼠总的睡眠时间延长,并选择性使深睡时间明显延长,对异相睡眠影响小,提示在镇静催睡功能上它的副作用很小。
Objective To study the effects of Semen ziziphi spinosae decoction on sleeping states. Methods Polysomnography was used to record the changes of EEG and EMG in rats in different sleeping states, and the influences of Semen ziziphi spionsae decoction on them were observed. Results After intragastric administration with Semen ziziphi spinosae decoction （ 17.5 g/kg crude drug） for 7 days, TST and SWS2 were increased in free - moving rats, but SWS1 and REMS had no significant changes. Conclusion The decoction of Semen ziziphi spinosae can prolong TST of rats, selectively increase SWS2 and has no obvious changes in REMS, indicating it has few side - effects.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第6期1317-1318,共2页
Lishizhen Medicine and Materia Medica Research
基金
黑龙江省自然科学基金资助项目(No.D0317)
关键词
多导睡眠图
酸枣仁水煎液
Sleeping states
Semen ziziphi spinosae decoction
