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浸润性乳腺癌中胸苷磷酸化酶(TP)和血管内皮生长因子(VEGF)的表达及与肿瘤微血管密度(MVD)的关系 被引量：1

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摘要 目的揭示TP在乳腺癌中表达的有关临床病理学意义,及其与VEGF等在乳腺癌血管生成及进一步的恶性进展中的相互作用及其机制,为今后乳腺癌的个体化和靶向性治疗提供参考。方法应用免疫组化法检测TP、VEGF、在128例浸润性乳腺癌标本及24例乳腺良性病变中的表达,用CD34检测乳腺组织中的MVD,分析各指标间的相互关系。结果浸润性乳腺癌组织中TP、VEGF的表达明显高于正常组织,TP高表达组中MVD明显高于TP低表达组。TP、VEGF的表达及MVD与TNM临床分期、组织学分级呈正相关,TP与VEGF的表达及MVD呈正相关。TP表达率与患者淋巴结有无转移无关。结论乳腺癌TP、VEGF表达与其组织学分级和血管生成有关。
作者 张刚 邢智勇 李中
机构地区 河北大学附属医院肿瘤科 河北大学医学部
出处 《河北职工医学院学报》 2008年第3期38-40,共3页 Journal of Hebei Medical College for Continuing Education
关键词 胸苷磷酸化酶 乳腺癌 血管内皮生长因子 5-FU 预后 免疫组化
分类号 R737.9 [医药卫生—肿瘤]
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参考文献16

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二级参考文献45

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河北职工医学院学报
2008年 第3期

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