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海洋放线菌Streptomyces sp.(#195-02)的代谢产物研究 被引量:11

Secondary Metabolites of a Marine Actinomycete Streptomyces sp.(No.195-02) from South China Sea
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摘要 从一株南海海洋链霉菌属放线菌195-02中分离得到8个化合物,利用波谱技术确定其结构分别为对羟基苯腈(1)、2-甲基-3-呋喃甲酸(2)、2-呋喃甲酸(3)、环(苯丙-苯丙)二肽(4)、环(亮-异亮)二肽(5)、烟酸(6)、吲哚-3-乙酸(7)和邻苯二甲酸二(2-乙基己基)酯(8)。化合物1、3、8为首次从链霉菌属中分离得到,化合物4~7为首次从海洋放线菌中分离得到。活性测试表明化合物4和5在浓度为50μg/ml时,对喉癌细胞hep2抑制率分别为51%和47%,对肝癌细胞hepG2抑制率分别为40%和31%。 The metabolites of a marine streptomyces sp.actinomycete(No.195-02) were studied and eight compounds were isolated from the fermentation liquid.structures were elucidated by spectroscopy methods as p-hydroxy-benzonitrile(1),2-methyl-furan-3-carboxylic acid(2),furan-2-carboxylic acid(3),cyclo(Phe-Phe)(4),cyclo(Leu-Ileu)(5),nicotinic acid(6),2-(1H-indol-3-yl) acetic acid(7) and bis(2-ethylhexyl) phthalate(8).The compounds 1、3 and 8 were firstly isolated from Streptomyces sp.,compounds 4~7 were firstly found from marine actinomycetes.Coumpouds 4 and 5 evidently inhibited the growth of cancer cell lines hepG2 and hep2 at the concentration of 50μg/ml.
出处 《中药材》 CAS CSCD 北大核心 2008年第5期645-647,共3页 Journal of Chinese Medicinal Materials
基金 国家863科技攻关计划资助项目(2003AA624010) 国家自然基金资助项目(20572136) 华南农业大学新学科及大型仪器使用基金(2006X013、2007Y006)
关键词 海洋放线菌 次级代谢产物 链霉菌 环二肽 细胞毒 Marine actinomycete Secondary metabolite Streptomyces sp. Cyclodipeptide Cytotoxic
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