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姜黄素水溶性制剂对小鼠黑素瘤自发性转移的抑制作用 被引量：6

Inhibitory effect of water-soluble preparation of curcumin on spontaneous metastasis of B16F10 melanoma in mice
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摘要 目的:观察姜黄素水溶性制剂对小鼠黑素瘤转移的抑制作用。方法:以羟丙基-β-环糊精(hydroxypropyl-β- cyclodextrin,HP-β-CD)为包合剂制备姜黄素水溶性制剂——姜黄素-羟丙基-β-环糊精包合物(C-HP-β-CD),采用小鼠黑素瘤细胞B16J10建立小鼠移植瘤伴自发性转移模型,于移植瘤细胞的第2日开始以腹腔注射药物进行治疗,共分低剂量姜黄素组(30 mg/kg)、高剂量姜黄素组(60 mg/kg)、阴性对照组及阳性对照TNP-470组(30 mg/kg)4组,隔日1次,连给7次。观察各组小鼠成瘤及腹腔淋巴结转移情况,以免疫组化法检测移植组织的微血管密度(MVD)。结果:制备的C-HP-β-CD易溶于水,不加任何有机溶剂即可用于腹腔注射给药。两个C-HP-β-CD治疗组的肿瘤移植瘤均明显小于阴性对照组(P<0.05),移植瘤组织MVD均明显低于阴性对照组(P<0.05)。高剂量姜黄素组的腹腔淋巴结转移程度显著低于阴性对照组(P<0.05),但低剂量姜黄素组则与阴性对照组无显著差异(P>0.05)。结论:姜黄素水溶性制剂经腹腔注射给药时可显著抑制小鼠黑素移植瘤转移,且其抗转移作用与抗血管生成作用密切相关。
作者 李剑明 杨和平 白中红 许软成
机构地区 解放军第 第三军医大学附属西南医院呼吸科
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 2008年第3期286-288,共3页 Chinese Journal of Cancer Biotherapy
关键词 姜黄素 水溶性制剂 黑素瘤 肿瘤转移 血管生成
分类号 R739.5 [医药卫生—肿瘤] R730.52 [医药卫生—肿瘤]
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参考文献16

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二级参考文献22

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共引文献57

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引证文献6

二级引证文献35

中国肿瘤生物治疗杂志
2008年 第3期

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