摘要
目的:探讨脂蛋白(a)[Lp(a)]及超敏C反应蛋白(hs-CRP)水平对冠状动脉病变程度的预测价值。方法:入选行冠状动脉造影病例580例,根据冠状动脉病变程度分三组:A组(冠脉狭窄≤30%)154例;B组(冠脉狭窄31%～69%)243例;C组(冠脉狭窄≥70%)183例。对Lp(a)及hs-CRP水平与冠状动脉病变程度的相关性进行分析。结果:(1)随冠状动脉病变程度加重,总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)、Lp(a)及hs-CRP浓度逐渐增加。与A组比较,B组及C组各指标均有显著性增加(P<0.05或<0.01)。与B组比较,C组Lp(a)及hs-CRP有显著性增加(P<0.01);(2)多元逐步回归分析显示,按标准回归系数大小1.415～1.106顺序,相关因素为Lp(a)、hs-CRP、LDL-C和ApoB(P<0.05～<0.01),Lp(a)联合hs-CRP可使OR值进一步增高(P<0.05)。结论:Lp(a)及hs-CRP对冠状动脉病变程度的预测价值并不优于其他血脂指标,联合二者可提高其预测价值。
Objective.. To evaluate the predict value of lipoprotein （a） [ Lp （a）], high-sensitive C-reactive protein （hs-CRP） and their combination on coronary artery stenosis in patients with coronary artery disease. Methods： A total of 580 patients underwent coronary angiography were divided into three groups： group A of 154 cases （stenosis less than 30%）, group B of 243 cases （stenosis from 31 to 69%）, group C of 183 cases （stenosis）70%）. The relationship among Lp （a）, hs-CRP and severity of coronary artery disease by angiography were analyzed. Results： （1） Significant statistical differences were found between the three groups for the parameters included total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, apolipoprotein B （Apo B）, Lp （a） and hs-CRP （P〈0. 05, （0.01） ; Compared with group B, the Lp （a） and hs-CRP significantly increased （P〈0.01） in group C; （2） Logistic regression analysis showed that Lp （a） and hs-CRP positively correlate with coronary artery disease （standard regression coefficient 1. 415, 1. 329, P（0.01）, Lp （a） combined with hs-CRP would further elevated predicative value （P〈0. 05）. Conclusion： Lp （a） and hs-CRP levels are significant risk determinants for CAD, the predicative value of Lp （a） or hs-CRP is not better than other blood lipids, but concomitant evaluation of Lp （a） and hs-CRP may improve predicative value for CAD.
出处
《心血管康复医学杂志》
CAS
2008年第3期217-220,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
