摘要
目的探讨黏液炎性纤维母细胞肉瘤与结节性腱鞘炎的相关意义。方法对1例复发于结节性腱鞘炎的黏液炎性纤维母细胞肉瘤进行光镜和免疫组织化学检查。结果证实黏液炎性纤维母细胞肉瘤具有特征性异型细胞,包括假脂肪母细胞、印戒样细胞及相似于病毒细胞、神经节细胞和R-S细胞。组织结构由明显黏液样区、纤维透明变性和炎症性病变混杂组成。肿瘤细胞表达vimentin弥漫阳性,CD34和CD68部分阳性,大多数淋巴细胞表达CD3和CD45RO阳性。结节性腱鞘炎不出现特征性异型细胞和明显黏液样区。结论黏液炎性纤维母细胞肉瘤是一种低度恶性肿瘤,好发于肢端,生长缓慢,复发率高,与肢端结节性腱鞘炎的临床病理和免疫表型有明显相似处,惟没有特征性异型细胞和明显黏液,M IFS和结节性腱鞘炎相互关系有待进一步研究。
Purpose To investigate the significance of the relationship between myxoinflammatory fibroblastic sarcoma （MIFS） and nodular tendosynovitis. Methods One case of MIFS arising from nodular tendosynovitis was studied by fight microscopy, and immunohistochemistry. Results MIFS showed distinctive atypical cells, including pseudolipoblasts, signet-ring llke cells and resembling virocytes, ganglion cells or R-S like cells, The architecture of MIFS was characterized by the mixture of prominent myxoid areas, fibrous hyaline degeneration zone and prominent inflammatory change. The tumor cells were diffusely positive for vimentin with locally positive for CD34 and CD68. Most lymphocytes showed immunoreactive to CD3 and CD45RO. Distinctive atypical cells and obvious myxoid areas were not observed in nodular tendosynovitis. Conclusions MIFS is an low-grade malignant tumor, Most occurs in the distal extremities and grows slowly with a high rate of local recurrence. MIFS and nodular tendosynovitis have prominent similar features in clinical pathology and immunopbenotype with the latter absent from characteristic atypical cells and myxoid areas. The interactive relationship between MIFS and nodular tendosynovitis awaits further studies.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2008年第3期317-319,共3页
Chinese Journal of Clinical and Experimental Pathology
