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盐酸丁螺环酮缓释片的制备及其体外释放度考察

Preparation of Buspirone Hydrochloride Sustained-Release Tablets and Release Behavior in vitro
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摘要 目的:制备盐酸丁螺环酮缓释片并探讨其体外释放机理。方法:以羟丙基甲基纤维素(HPMC)为骨架材料,以乳糖、可压性淀粉、微晶纤维素调节释放度,采用正交试验法进行处方优化,用数学模型拟合释放曲线。结果:HPMC、乳糖的用量对释药有显著性影响,盐酸丁螺环酮缓释片的体外释药符合零级释放模型。结论:盐酸丁螺环酮缓释片处方设计合理,可进一步开发。 Objective: To prepare sustained release tablets of buspirone hydroehloride and study the release mechanism. Method: HPMC was used as the gel matrix. Lactose, starch and MCC were used to modify the release. Orthogonal experiment was carried out to optimize the formulation. Mathematic models were used to imitate the drug release. Result: The amount of HPMC and lactose had significant effects on the release of buspirone hydroehloride. The release behavior of the tablets followed the zero order equation. Conclusion: The formula of the sustained release tablets is reasonable and it is worth doing further research.
作者 张韵 廖华卫
出处 《中国药师》 CAS 2008年第6期631-633,共3页 China Pharmacist
关键词 盐酸丁螺环酮 缓释片 体外释放度 Buspirone hydroehloride Sustained-release tablets Release rate in vitro
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