摘要
为了解门诊病人抗精神病药（ＡＰＤ）使用频度、治疗方案、药物副反应和疗效，采用分层随机方法抽取４８１例病人，用半定式表格填写自制的精神药物使用调查表。结果发现，门诊使用ＡＰＤ前３位药品为氯丙嗪、氯氮平及奋乃静，治疗方案前３位为氯丙嗪、氯氮平及氯丙嗪＋氯氮平；发现治疗剂量＜４００ｍｇ／ｄ组病人，药物副反应轻，疗效亦较好；单一治疗组副反应较合并及联合用药组轻，且疗效明显较好。有５３．６％的病人使用安坦，其中３７．２％的病人为预防性使用安坦。作者认为门诊病人尽量单一应用ＡＰＤ治疗，维持治疗剂量宜在４００ｍｇ／ｄ以下，不主张长期或预防性使用安坦。
Objective:To study the use of antipsychotic drugs in psychiatric outpatients. Method:Four hundred and eighty one psychiatric outpatients recruited randomly from an outpatient department completed a semi-structured questionnaire.Results were matched with case records. Results:Chlorpromazine,clozapine and perphenazine ranked the top three commonly used antipsychotics.The three most popular treatment regime were chlorpromazine,clozapine and a combination of chlorpromazine and clozapine respectively.Patients on single drug regime or receiving less than 400mg chlorpromazine equivalent daily did better than those on multiple drugs or receiving higher dose in terms of clinical response and side effects.Fifty three percent patients were taking benzhexol while thirty seven percent took it as prophylactic against extrapyromidal side effects. Discussion:Single drug regime should be adopted in most cases.A daily maintenance dose of less than 400mg chlorpromazine equivalent is perferred.Long term and prophylactic use of benzhexol is not recommended.
出处
《临床精神医学杂志》
1997年第6期326-328,共3页
Journal of Clinical Psychiatry
关键词
门诊病人
抗精神病药
剂量
副反应
疗效
Psychiatric outpatients Antipsychotics Side effects Dosage
