期刊文献+

水溶性壳聚糖季铵盐的制备工艺研究 被引量:9

A study on the preparation of water-souble quaternary ammonium salt of chitosan
下载PDF
导出
摘要 采用2,3-环氧丙基三甲基氯化铵(GTA)和脱乙酰度95%的壳聚糖为原料制备了水溶性壳聚糖季铵盐2-羟丙基三甲基氯化铵壳聚(HTCC)。研究了反应时间、反应温度、投料物质的量比和壳聚糖分子量等因素对产率以及水溶性的影响。采用正交试验确定了最佳工艺条件:反应时间12h,反应温度80℃,n(GTA):n(-NH2):4.5:1,壳聚糖分子量6.3×10^4,产率94.8%。 N-1-(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride(HTCC) was prepared by the reaction of chitosan (DE)= 95%)with 2,3-epoxypropyltrimethylammonium chloride (GTA). The effect of reaction time, reaction temperature, molecular weight of chitosan, molar ratio of reactants, etc. on yield and the water solubility of HTCC was studied. The optimal conditions were obtained by the orthogonal test. As a result, the optimum reaction conditions were as follows: reaction time 12 h, reaction temperature 80 ℃ ,n(GTA): n(--NH2) =4. 5 : 1 ,molecular weight 63 000. The yield of reaction was 94. 8%.
出处 《化工科技》 CAS 2008年第3期26-31,共6页 Science & Technology in Chemical Industry
关键词 壳聚糖季铵盐 2-羟丙基三甲基氯化铵壳聚糖 水溶性 制备工艺 正交试验 Quaternized chitosan HTCC Water soluble Preparation Orthogonal test
  • 相关文献

参考文献19

  • 1Thomas Kean, Susanne Roth, Maya Thanou. Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency [J]. Journal of Controlled Release, 2005,103 : 643-653.
  • 2Mi F L, Shyu S S, Chen C T, et al. Adsorption of indomethacin onto chemically modified chitosan beads[J']. Polymer, 2002,43 : 757-765.
  • 3Jie Wu,Zhi-Guo Su,Guang-Hui Ma. A therrno-and pH-sensitive hydrogel composed of quaternized chitosan/glycero- phosphate [J]. International Journal of Pharmaceutics, 2006,315:1-11.
  • 4徐淑芳,徐咏梅,陈建钢.壳聚糖季铵盐纳米粒子的制备、表征及其缓释蛋白质药物性能[J].武汉大学学报(理学版),2004,50(6):721-725. 被引量:10
  • 5Milena Ignatova, Starbova K, Markova N, et al. Rashkov Ⅰ electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol)[J]. Carbohyd Res, 2006,341 : 2 098-2 107.
  • 6Milena Ignatova, Nevena Manolova, Iliya or. Novel antibacterial fibers of quaternized chitosan and poly(vinyl pyrrolidone) prepared by electrospinning [J]. European Polymer Journal,2007,43:1 112-1 122.
  • 7Arunima Saxena, Arvind Kumar, Vinod K Shahi. Preparation and characterization of N-methylene phosphonic and quaternized chitosan composite membranes for electrolyte separations [J]. Journal of Colloid and Interface Science, 2006,303:484-493.
  • 8黄瑞华,陈国华,王娟.新型季铵化壳聚糖/聚丙烯腈(PAN)复合纳滤膜的制备及其截留性能研究[J].现代化工,2006,26(z1):204-208. 被引量:11
  • 9肖玲,张婧.交联壳聚糖季铵盐与聚合铝复合的絮凝效果研究[J].环境科学与技术,2006,29(10):34-36. 被引量:13
  • 10Sang-Hoon Lim, Samuel M Hudson. Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group[J]. Carbohydrate Research, 2004,339: 313-319.

二级参考文献89

共引文献135

同被引文献116

引证文献9

二级引证文献37

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部