摘要
低聚壳聚糖(COS)经化学改性得到N-苯亚甲基壳聚糖(NBCOS)和O-2′-羟丙基三甲基氯化铵壳聚糖(OHCOS),对其结构进行表征。考察了COS及其衍生物对超氧阴离子O2·-、羟基自由基·OH、DPPH自由基的清除活性以及还原能力。结果表明:当浓度为10mg/mL时,COS和OHCOS对O2·-的清除率分别为89.6%和85.5%,而同样浓度时NBCOS的清除率仅有6.9%;它们清除·OH和DPPH的活性大小顺序为COS>OHCOS>NBCOS,而还原能力大小顺序为COS>NBCOS>OHCOS。
N-benzylidene chitosan oligosaccharide （NBCOS） and O-2-hydroxypropyltrimethylammonium chloride chitosan oligosaccharide（OHCOS） were synthesized from chitosan oligosaccharide （COS）. COS and its derivatives were evaluated for the scavenging of superoxide anion O2^·-, hydroxyl radical · OH and DPPH radical and for reducing power. At a concentration of 10 mg/mL,the scavenging effects of COS and OHCOS towards O2^·- were 89.6% and 85.5% ,respectively,whereas the inhibiting rate of NBCOS was 6.9%. The orders of scavenging activity against ·OH and DPPH were：COS 〉 OHCOS 〉 NBCOS,the reducing power order was：COS 〉 NBCOS 〉 OHCOS.
出处
《天然产物研究与开发》
CAS
CSCD
2008年第3期530-533,共4页
Natural Product Research and Development
基金
上海市教育委员会科研项目(07zz134)
上海市重点学科建设项目专项基金(T1102)
关键词
低聚壳聚糖
季铵盐
席夫碱
抗氧化
还原能力
chitosan oligosaccharide
quartemary ammonium salt
schiff-base
antioxidant activity
reducing power
