摘要
目的探讨血清胶质纤维酸性蛋白（GFAP）与高血压脑出血的关系。方法采用酶联免疫吸附法对68例急性高血压脑出血患者血清GFAP水平进行动态观察,分析其与出血量、出血部位、神经功能缺损程度评分及预后的关系,并与正常对照组比较。结果高血压脑出血患者发病1-14d血清GFAP水平明显高于正常对照组（均P〈0.001）;发病1-14d血清GFAP水平与出血量正相关（r1=0.375,P〈0.05;r3=0.425,P〈0.05;r7=0.614,P〈0.01;r14=0.532,P〈0.01）;也与NDS评分正相关（r1=0.476,P〈0.05;r7=0.637,P〈0.01）;与出血部位不相关;发病后血清GFAP〉20ng/ml的患者预后不佳。结论高血压性脑出血患者血清GFAP水平明显升高,并且与出血量、病情和预后相关。
Objective To investigate the association between serum glial fibrillary acidic protein （GFAP） and hypertensive intracerebral hemorrhage （HICH）. Methods The level of serum GFAP was detected in 68 patients with HICH by enzyme linked immunosorbent assay（ELISA） and its relationship with bleeding volume, bleeding part, neural deficit score（NDS） and prognosis was analysed, also compared those with the normal control （NC） group. Results Compared with NC group, the levels of serum GFAP in HICH group were increased significantly in 1 - 14 d after onset （ all P 〈 0. 001 ）. The levels of serum GFAP in HICH group had positive correlation with bleeding volume （r1 =0.375,P〈0.05;r3 =0.425,P〈0.05; r7 =0.614,P〈0.01; r14 =0.532,P〈0.01） and NDS（r1 = 0. 476 ,P 〈 0. 05 ;r7 = 0.637, P 〈 0. 01 ）, but no correlation with bleeding part. The patients with the level of serum GFAP 〉 20 ng/ml had worse prognosis. Conclusions The level of serum GFAP in patients with HICH is increased significantly, and it is correlate with bleeding volume, condition and prognosis.
出处
《临床神经病学杂志》
CAS
北大核心
2008年第3期227-229,共3页
Journal of Clinical Neurology
关键词
高血压脑出血
胶质纤维酸性蛋白
hypertensive intracerebral hemorrhage
glial fibrillary acidic protein
