摘要
目的：观察曲马多对七氟醚吸入麻醉后不同年龄患儿苏醒期躁动的预防作用。方法：择期行扁桃体切除术的患儿80例，年龄3～9岁，ASAⅠ级。随机分为学龄前儿童（3～5岁）曲马多组（M1组）及其对照组（D1组）；学龄儿童（6～9岁）曲马多组（M2组）及其对照组（D2组）。每组20例。4组患儿均给予8％七氟醚＋吸氧（5L·min^-1）及等量芬太尼静注诱导，曲马多组（M1、M2组）在麻醉诱导后静脉注射曲马多2mg·kg^-1，七氟醚2％～3％＋吸氧2L·min^-1维持麻醉。结果：4组的手术时间、拔管时间无明显差异。与D1组相比，M1组躁动发生率有一定的下降，但无统计学意义（P〉0、05）；M2组与D2组相比，苏醒期呛咳、躁动发生率明显下降（P〈0．05）。结论：曲马多可以有效地预防学龄儿童七氟醚吸入麻醉术后躁动的发生，对学龄前儿童无明显作用。
Objective To observe preventive effects of tramadol on postoperative restlessness in children after inhalational sevoflurane. Methods Eighty children, aged 3 - 9 years old, undergoing selective tonsillectomy （ ASA Ⅰ）, were randomly divided into （n = 20） ： the preschool children （3 -5 years old） tramadol group （ M1 group） and the control group （ D1 group ） ; the school children （6 - 9 years old ） tramadol group （ M2 group） and the control group （ D2 group）. Four groups of children were induced by 8% sevoflurane ＋ oxygen （5 L·min^-1 ） and the equivalent dose of fentanyl. In M1 and M2 group, tramadol （2 mg·kg^-1） was administered intravenously after inhalation induction. 2% - 3% sevoflurane ＋ oxygen （2 L·min^-1 ） was used to mantain the depth of anesthesia. Results There was no significant difference of operating time and extubating time among four groups. Compared with the D1 group, the restlessness incidence in recovery period in M1 group decreased slightly, but there was no statistic difference （ P 〉 0.05 ） ; Compared with the D2 group, the incidence of choking and restlessness in M2 group decreased significantly （ P 〈 0.05）. Conclusion Tramadol could prevent restlessness effectively in school children receiving inhalational sevoflurane. But tramadel has no significant effect on pre-school children.
出处
《东南大学学报（医学版）》
CAS
2008年第4期294-296,共3页
Journal of Southeast University(Medical Science Edition)
关键词
曲马多
七氟醚
躁动
儿童
tramadol
sevoflurane
restlessness
children
