摘要
目的观察阿司匹林对庆大霉素耳毒性的预防作用。方法设计实施多中心的随机双盲对照试验,预防组在应用庆大霉素的同时口服阿斯匹林2周,对照组口服安慰剂。用药前后检测纯音测听3次,对比听力损伤发生率。结果两组的血清庆大霉素水平相当,预防组的听力损伤发生率为3%(3/89),明显低于对照组的13%(14/106)(P=0.013)。试验中阿司匹林没有影响到庆大霉素的血清药物水平和时程。结论同时伍用阿司匹林可以有效减轻庆大霉素的耳毒性损伤,氨基甙类抗生素的耳毒性防护研究已从动物实验走向临床。
Objective To investigate the protection of aspirin against ototoxicity of aminoglycosides in a clinical trial. Methods A multi-centre randomized double-blind placebo-controlled study in patients receiving gentamicin for acute infections was conducted. Pure tone audiometry was performed 3 times before and after treatment to compare the incidence of hearing loss between the two groups. Results Fourteen of 106 patients （13%） met the criterion of hearing loss in the placebo group while only 3/89 （3%） were affected in the aspirin group （P= 0.013）. Aspirin did not influence gentamicin serum levels or the course of therapy. Conclusion These results indicate that therapeutic protection from aminoglycoside ototoxicity may be extrapolated from animal models to the clinic. Aspirin can significantly attenuate the risk of gentamicin-induced hearing loss.
出处
《中华耳科学杂志》
CSCD
2008年第2期145-147,共3页
Chinese Journal of Otology
