摘要
目的观察在综合治疗基础上,使用糖皮质激素对慢性阻塞性肺疾病(COPD)急性加重期的临床疗效。方法慢性阻塞性肺疾病急性加重期患者随机分为地塞米松组、甲强龙组和普米克令舒组。综合治疗给予氧疗、抗感染、止咳、祛痰、纠正酸碱平衡等;在上述治疗基础上加用静脉滴注地塞米松(5 mg Qd,共3天)、甲基强的松龙(80 mg Qd,共3天),雾化吸入普米克令舒(2 mg Q8 h,共3天)治疗。3组患者治疗后进行临床症状评分、检测肺功能和动脉血气变化等参数,并进行对比分析。结果各治疗组生活质量明显改善,治疗后肺功能检查FEV1和FEV1/FVC明显高于治疗前,地塞米松组与甲强龙组、普米克令舒组比较差异有非常显著性(P<0.01),甲强龙组与普米克令舒组比较无统计学差异(P>0.05)。普米克令舒组的不良反应少于地塞米松组和甲强龙组。结论糖皮质激素对COPD急性加重期有较好的近期疗效,普米克令舒疗效明显优于地塞米松,但与甲强龙疗效的差异无显著性。普米克令舒雾化治疗是COPD急性加重期糖皮质激素治疗的有效选择。
Objective To observe the clinical effect of glucocorticostteroid on acute exacerbation of chronic obstructive pulmonary disease based on comprehensive treatment. Methods Acute exacerbation of chronic obstruetive pulmonary disease（COPD） were randomly divided into three treatment groups： dexamethasone group, solumedrol group and puhnieort respules group. These groups were given antibiotics, oxygen and treatment for expeetoration, relieved cough and retrieved acid- base equilibrium. Each group was given the therapies mentioned above and dexamethasone 5 rag once a day for 3 days, Methylprednisolone 80 mg once a day for 3 days, Pulmicort respules for inhalation 2 mg Q8 h for 3 days respectively. The clinical symptom score, the pulmonary function and arterial blood gases were measured and observed before and after treatment. Results The significant difference was seen between puhnieort respules group and dexanlethasone group before and after treatment（ P 〈 0.01 ）. The significant difference was not found among the solu - medrol group and puhnicort respules group （ P 〉 0. 05 ）. Conclusions Puhnicoll respules is effective for acute exeerbation of COPD.
出处
《南华大学学报（医学版）》
2008年第1期67-70,共4页
Journal of Nanhua University(Medical Edition)
