摘要
通过克拉霉素结晶母液回收工艺研究提高产品的回收率,文中采用了4步过程回收克拉霉素结晶母液中的产品,包括粗品分离、二次溶剂萃取和产品结晶过程。实验结果表明:粗品分离过程中,浓缩物和水质量比为2.5∶1,过滤温度40℃时克拉霉素收率最高;溶剂萃取过程中,采用浓缩萃取液与改变温度的方法可提高产品纯度;克拉霉素的总收率达到47.8%,产品中克拉霉素和6,11-O-双甲基红霉素质量比由粗品中的约1∶1提高至52∶1。克拉霉素总回收率得到提高,给工业化生产带来较高的经济效益。
To improve the clarithromycin recovery of the production, the four-stage process including the isolation of crude solid, two-step solvent extraction and product crystallization were used for clarithromycin recovery from crystal mother liquors. The results show that in the isolation process of crude solid, the mass ratio of concentrated solution to water is 2.5 ： 1, and the temperature of filtration is 40℃. The product purity was increased by distillation of solvent and change of temperature. The total yield of clarithromycin was 47. 8%. The mass ratio 1 ： 1 of clarithromycin to 6, 11-di-OMe erythromycin A in crude mixture was improved to 52： 1. The recovery of clarithromycin was improved and it can bring a lot of benefits to industrial production.
出处
《化学工程》
EI
CAS
CSCD
北大核心
2008年第6期64-67,共4页
Chemical Engineering(China)
基金
天津市应用基础重点资助项目(033804511)
关键词
克拉霉素
6
11-O-双甲基红霉素
分离
溶剂萃取
结晶
clarithromycin
6,11-di-OMe erythromycin A
isolation
solvent extraction
crystallization
