摘要
目的:研究银杏叶提取物抗脑缺血再灌注损伤作用与线粒体ATP敏感性钾通道(mitoKATP)开放的关系。方法:用大脑中动脉线栓法(MCAO)制作大鼠局灶性脑缺血再灌注损伤模型。造模前静脉给予银杏叶提取物15mg·kg-1和(或)选择性mitoKATP拮抗剂5-羟基癸酸(5-HD)10mg·kg-1预处理,以脑梗死体积、神经缺陷评分、SOD活性和丙二醛含量,评价银杏叶提取物抗脑缺血再灌注伤的作用与mitoKATP的关系。结果:银杏叶提取物具有改善大鼠缺血再灌注引起的脑功能和组织损伤,但此作用可被预先给予的5-HD减弱。结论:银杏叶提取物抗脑缺血再灌注伤作用与mitoKATP开放有关。
Objective ：To study on the relationship between the protection of ginkgo biloba extract（ Egb761 ） against focal cerebral ischemia- reperfusion injury and mitochondrial ATP- sensitive potassium channels（mitoKATP） in vivo. Methods：A reversible middle cerebral artery occlusion model（MCAO） was used in this study. Fourty male Sprague -dawley rats were divided into four groups （n = 10） ： MCAO group, Egb761 group （ 15mg·kg^-1）, 5 - HD group （ 10mg·kg^-1） ,5 -HD ＋ Egb761 group. The neurological funciton was scored and the infarct volume,activity of SOD,content of MDA were measured after operation. Results ：In 5 - HD ＋ Egb761 group, the infarct volume, the neurological funeiton were significantly higher than those in Egb761 pretreated group. Conclusion ：The result is suggested that the protects of Egb761 against focal cerebral isehenfia - repefusion injury may be related to mitoKATP.
出处
《中华中医药学刊》
CAS
2008年第7期1462-1463,共2页
Chinese Archives of Traditional Chinese Medicine
基金
湖南省医药卫生科研计划课题项目(B2005116)
湖南省教育厅科研计划课题项目(07C712)
关键词
银杏叶提取物
ATP
钾通道
脑缺血
ginkgo biloba extract
ATP
potassium channels
cerebral isehemia
