摘要
1例70岁男性患者,因上呼吸道感染静脉输注左氧氟沙星0.2g,2次/d,口服双黄连口服液10ml,3次/d。静脉输注左氧氟沙星第3次后出现手指关节痛,输注第5次后,手指关节疼痛肿胀加重,并累及腕、肩、肘、膝关节;且出现皮疹。实验室检查显示ALT1705U/L,AST754U/L。停用该药,并给予保肝及对症治疗。1周后,患者关节肿胀疼痛以及皮疹消退;ALT80U/L,AST恢复至正常范围。
A 70-year-old man with upper respiratory tract infection was administered with intravenous infusion of levofloxacin 0.2 g twice daily and oral Shuanghuanglian solution 10 ml thrice daily. After the third infusion of levofloxacin, the man experienced pain of finger joints. And after the fifth infusion of levofloxacin, his painful swelling of finger joints worsened, and wrist, shoulder, elbow, and knee joints were involved; skin rash occurred. Laboratory investigations revealed the following levels： ALT [ 705 U/L, AST 754 U/L. Levofloxacin was withdrawn, and he received liver-protective and symptomatic treatment. One week later, his painful swelling of joints and skin rash resolved, his ALT level was 80 U/L, and his AST level returned to normal range.
出处
《药物不良反应杂志》
2008年第3期208-208,共1页
Adverse Drug Reactions Journal
关键词
左氧氟沙星
关节肿痛
肝功能异常
levofloxacin
painful swelling of joint
abnormal liver function
