摘要
为探讨先天性心脏病的遗传方式，对３７５例先天性心脏病进行了遗传流行病学研究，结果显示该病一级亲属患病率为６．９％，遗传度６６．１３％±１．１３％；二级亲属患病率为１．７％，遗传度为３８．２５±８．３％，一、二级亲属加权平均遗传度为６５．６５±１．０９％，遗传因素较为重要。在各级亲属患病中，患病率依次为一级亲属（６．９％）、二级亲属（１．７％）、一般群体（０．８６％）。所以该病基本符合多基因遗传方式。
In order to explore the genetic model of congenital heart disease (CHD),375 individuals of CHD were investigated.The results showed that the incidence of primary relatives was 6.9% , the heritability was 66.13 ±1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25±8.3% respectively.The average heritability among primary,secondary relatives was 65.65±1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed:primary relatives (6.9%)> secondary relatives (1.7%)> distant relatives (0.86%) and was in accordance with polygenic incidence,suqqesting that gene play an important role in the liability variation of CHD.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
1997年第4期224-226,共3页
Chinese Journal of Epidemiology
基金
山东省计生委资助
关键词
遗传度
流行病学
先天性心脏病
Heritability Epidemiology Congenital heart disease
