摘要
目的观察高容量血液滤过对多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)患者细胞因子及Logistic器官功能障碍评分(Logistic organ dysfunction system,LODS)的影响,探讨高容量血液滤过对MODS患者的治疗作用。方法31例行高容量血液滤过治疗的MODS患者为研究对象,比较他们治疗前后TNF-α、IL-6、IL-8水平和LODS评分的变化。结果高容量血液滤过治疗后的MODS患者细胞因子TNF-α、IL-6、IL-8水平及LODS评分与治疗前比较明显降低(t=12.47、14.85、10.60、13.70,P<0.05)。结论高容量血液滤过能降低MODS患者炎症介质水平,降低MODS患者LODS评分,改善MODS患者的预后。
Objective To observe the effects of high-volume hemofiltration（HVHF）on the cytokines and Logistic organ dysfunction system（LODS）in the patients with multiple organ dysfunction syndrome and to investigate the therapeutic action of HVHF for the patients with MODS.Methods The levels of TNF-α,IL-6,IL-8 and the LODS scores in the patients with MODS undergoing HVHF were measured before HVHF and after HVHF respectively.Result The levels of TNF-α,IL-6,IL-8 and the LODS scores in the patients with MODS before HVHF were higher than those after HVHF（t=12.47,14.85,10.60,13.70,respectively,P〈0.05）.Conclusions HVHF could decrease the levels of inflammatory mediator and the LODS scores in the patients with MODS,and improve the survival rate of MODS patients.
出处
《中国急救医学》
CAS
CSCD
北大核心
2008年第6期536-538,共3页
Chinese Journal of Critical Care Medicine
基金
深圳市科技局科研计划项目(No.200304086)
