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黄芪甲苷的大鼠在体肠吸收动力学的研究 被引量:19

Study on absorption kinetics of astragalosideⅣin rats intestines
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摘要 目的:研究黄芪甲苷的在体肠吸收机制。方法:采用大鼠在体单向肠灌流实验,利用HPLC法测定黄芪甲苷的含量,分别研究吸收部位、药物浓度、P-糖蛋白抑制剂对黄芪甲苷吸收的影响。结果:各肠段的吸收速率常数(K_a)和表观吸收系数(P_(app))有显著性差异(P<0.05);在20~80 mg·L^(-1)内,小肠吸收速率常数和表观吸收系数无显著性差异;P-糖蛋白抑制剂对黄芪甲苷的肠吸收影响不大。结论:黄芪甲苷的肠吸收为典型的被动扩散吸收机制。 Objective: To investigate the mechanisms of intestine absorption of astragaloside Ⅳ in rat. Method: The Ka and Papp of astragaloside Ⅳ was investigated using single-pass intestinal perfusion technique in rats. HPLC was used to determine the concentration of astragaloside Ⅳ. The effect of absorption site, drug concentration and the inhibitors of P-glycoproteon on the absorption had been studied. Result: By the testing of the statistics, the Ka and the Papp values of the duodenum, jejunum, ileum, colonic had significant differences (P 〈 0. 05 ). The concentration from 20-80 mg ·L^-1 had no distinctive effect on the Ks and Papp of small intestine. The inhibitors of P-glycoproteon had no distinctive effect on the absorption of small intestine. Conclusion: Astragaloside Ⅳ is absorbed by typical passive diffusion mechanism.
出处 《中国中药杂志》 CAS CSCD 北大核心 2008年第13期1609-1611,共3页 China Journal of Chinese Materia Medica
基金 河北省中小企业创新基金(C7C1303192001)
关键词 黄芪甲苷 液相色谱法 单向灌流法 肠吸收动力学 astragaloside Ⅳ HPLC single-pass intestinal perfusion intestinal absorption kinetics
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