摘要
目的分析下呼吸道分离出的鲍氏不动杆菌耐药性及产β-内酰胺酶。方法用K-B法进行药物敏感性检测,按表型确证试验检测超广谱β-内酰胺酶(ESBLs),按表型筛选法检测高产AmpC酶。结果感染者多为呼吸重症监护病房(RICU)入院者,多有吸氧吸痰史,行气管插管、机械通气者15例,患者年龄大,使用过广谱抗菌药物;对头孢西丁、头孢唑林耐药率>93.0%,对氧氟沙星、阿米卡星耐药率均>70.0%,而对阿莫西林/克拉维酸、头孢他啶耐药率较低,<10.0%,ESBLs、AmpC酶检出率分别为16.0%、29.0%。结论鲍氏不动杆菌耐药率高,应加强药敏检测,指导临床合理应用抗菌药物,防止下呼吸道感染的暴发流行。
OKIECTIVE To study the drug resistance and β-lactamases produced by Acinetobacter baumannii isolated from lower respiratory tract. METHODS The drug sensitivity was detected with K-B test, and the ESBLs producing strains and β-lactamases strains were screened by double disk test and confirmed by the NCCLS confirmation test. RESULTS Patients mostly were old from RICU, and broad-spectrum antibiotic therapy was applied, with history of re-oxygenating, sputa extraction and invasive operation. Fifteen received mechanical ventilation. Results of drug sensitivity showed almost all were resistant to FOX and CFZ, more than 70 percent resistant to CXM and MEZ,IPM and SCF, less than 10 percent resistant to AMX/CLAV,CAZ and OXL. There were no strains showing drug resistance to IPM, CAZ/CA and SCF. Test showed 5 strains （16%） produced AmpC enzyme and 9 strains（29%） produced ESBLs enzyme. CONCLUSIONS Rate of drug resistance is high, so drug susceptibility test should be enforced to guide reasonably clinical applying antibiotics in order to prevent outbreaks.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第7期1022-1024,共3页
Chinese Journal of Nosocomiology
