期刊文献+

急性白血病患者化疗前后IL-2及IL-6水平测定的临床意义 被引量:9

Clinical significance of test on levels of IL-2 and IL-6 for AL patients before and after chemotherapy
下载PDF
导出
摘要 目的:探讨急性白血病患者化疗前后白介素-2(IL-2)及白介素-6(IL-6)水平变化对免疫功能影响的临床意义。方法:应用放射免疫分析法对57例急性白血病患者进行化疗后血清IL-2及IL-6含量检测,并与30例正常健康人作对照。结果:急性白血病初治组及短期完全缓解(CR)组IL-2水平分别为(18.69±9.41)ng/L,(29.36±6.30)ng/L,明显低于长期CR组(46.71±8.23)ng/L及正常对照组(53.62±8.86)ng/L;初治组及短期CR组IL-6水平分别为(125.86±15.78)ng/L,(82.27±10.21)ng/L,明显高于长期CR组(30.29±7.63)ng/L及正常对照组(23.46±6.32)ng/L。初治组IL-2和IL-6水平与长期CR组及正常对照组比较差异有显著性,P<0.05。结论:初治及短期CR急性白血病患者IL-2水平低、IL-6水平高,造成免疫抑制状态,白血病易复发。随着CR时间的延长,免疫状态逐渐恢复。 Objective:To probe into the clinical significance of influence of the changes of interleukin(IL) -2 and IL- 6 on immune function of acute leukemia (AL) patients before and after chemotherapy. Methods: With the radio - immuno - assay (RIA) used, the contents of IL- 2 and IL-6 in the serum of 57 cases AL patients after chemotherapy were tested, which had been compared with 30 cases healthy persons. Results : The levels of IL - 2 in AL initial treatment group and short - term complete relief (CR) group were respectively ( 18.69 ± 9.41 ) ng/L and (29. 36 ± 6. 30) ng/L, which were obviously lower than those in long -term CR group (46. 71 ±8.23) ng/L and healthy control group (53.62 ± 8.86) ng/L. The levels of IL - 6 in AL initial treatment group and short - term CR group were respectively ( 125.86 ± 15.78) ng,/L and (82. 27 ± 10.21 ) ng,/L, which were obviously higher than those in long - term CR group ( 30. 29 ± 7.63 ) ng/L and healthy control group (23.46 ± 6. 32) ng/L. The levels of IL - 2 and IL - 6 in initial treatment group had significant differences comparing with those in long - term CR group and healthy control group (P 〈 0.05). Conclusion:Of the AL patients in initial treatment group and short -term CR group, the level of IL - 2 is low and IL - 6 is high, by which the immuno - suppression condition will be formed and the AL is easy to recur. With the extending of CR time, the immune condition will gradually recover.
出处 《中国卫生检验杂志》 CAS 2008年第7期1372-1373,共2页 Chinese Journal of Health Laboratory Technology
关键词 白血病 完全缓解期 白介素-2 白介素-6 免疫功能 Acute leukemia Complete relief period Interleukin - 2 Interleukin - 6 Immune function
  • 相关文献

参考文献7

  • 1张之南,沈悌.血液病诊断及疗效标准[M].北京:科学出版社,2008.103-122,131-134,172-176.
  • 2Moqatlash S, Lutton JD. Leukemia cells and the cytokine netowork [J]. Proc Soc Exp Biol Med,2004,219(1) :27.
  • 3XaoLizhang, Yoshihiro, James, et al. Chipeta Intracellular cytokine profile off cells from children with acute lymphoblastic leukemia [ J ]. Cancer Immunol Immunother,2003, 49(3) : 172.
  • 4Yamazaki K, Yano T, Kameyama T, et al. Clinical significance of serum TH1/ TH2 cytokines in patients with pulmonary adenocarcinoma [J]. Surgery,2002, 131(1) : 236.
  • 5O'Surlivan B, Thomas R. CD40 and dendritic cell function [ J]. Crit Rev Immunol,2003,23(2) : 107.
  • 6Lemmink HH,Tuye L, Knd Q, et al. Identification of LIL - STAT in mono - cytic leukemia cells and monocytes after stimulation with interleukin - 6orinterferon gamma[ J]. Blood, 2003, 161 (13) : 3852.
  • 7李焱,索晓慧,牛志云.急性白血病患者化疗前后IL-2及IL-6水平的变化及临床意义[J].中国实验诊断学,2007,11(3):324-326. 被引量:8

二级参考文献6

  • 1Moqatlash S,Lutton JD.Leukemia cells and the cytokine netowork[J].Proc Soc Exp Biol Med,2004,219(1):27.
  • 2XaoLizhang,Yoshihiro,James,et al.Chipeta lntracellular cytokine profile ofT cells from children with acute lymphoblastic leukemia[J].Cancer Immunol Immunother,2003,49(3):172.
  • 3Yamazaki K,Yano T,Kameyama T,et al.Clinical significance of serum TH1/TH2 cytokines in patients with pulmonary adenocarcinoma[ J].Surgery,2002,131 (1):236.
  • 4O' Surlivan B,Thomas R.CD40 and dendritic cell function[ J].Crit Rev Immunol,2003,23(2):107.
  • 5Wadhwa M,Bird C,Page LL,et al.Quantitative biologic assay for individual cytokines[ M].In:Balkwill F R ed.Cytokines:a practical approach.New York:LRL Press,2003:360.
  • 6Lemmink HH,Tuye L,Knd Q,et al.Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6or interferon gamma[J].Blood,2003,161(13):3852.

共引文献57

同被引文献76

引证文献9

二级引证文献46

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部