摘要
缺血后处理的概念自2002年提出后,此后5年间的研究证实其可对器官缺血再灌注损伤起到极为有效的保护作用,作用机制大部分与缺血预处理类似,但仍有其独有的特点。再灌注损伤在器官移植术中不可避免,减轻再灌注损伤程度可促进移植器官功能的迅速恢复。相对于缺血预处理,缺血后处理具有良好的可控性,有望在器官移植术中得到良好的应用前景。深入了解缺血后处理对器官再灌注损伤保护作用的特点及机制,将有利于推动其在器官移植领域中的应用。
The concept of ＂ischemic postconditioning＂ was first raised in 2002,and the following 5 year research shows that it can protect organs from reperfusion injury.Although the mechanism of ischemic postconditioning is similar to ischemic preconditioning in many ways,it still has its own characteristics.Reperfusion injury is an inevitable problem in organ transplantation.It may accelerate the function recovery of the transplants to lessen the reperfusion injury.So ischemic postconditioning may have a fine prospect in organ transplantation for its good controllability during reperfusion.This article is going to briefly introduce the distinct mechanisms of ischemic postconditioning to protect organs from reperfusion injury and approach the possibilities of its application in organ transplantation.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2008年第6期548-552,共5页
Journal of Central South University ：Medical Science
关键词
缺血后处理
再灌注损伤
器官移植
ischemic postconditioning
reperfusion injury
organ transplantation
