摘要
由Ｌ—半胱氨酸与２—吡啶甲醛缩合制备了手性配体２—（２—吡啶基）—４—羧基—１，３—噻唑烷，并将其与〔Ｒｈ（ＣＯＤ）Ｃｌ〕２制备的在位催化剂用于苯乙酮的催化不对称硅氢化反应，可使该反应的化学产率高达９０％，光学收率达到７９７％ｅ．ｅ．
Chiral ligand,2-(2-pyridyl)-4-carboxy-1,3-thiazolidine,was synthezed through condensation of L-cysteine and α-pyridyl aldehyde.The in-situ catalyst prepared with this ligand and Rh(COD)Cl 2 is used to catalyze the asymmetric hydrosilation of accetophenone.The chemical yield and optical yield of the reaction could reach 90% and 79 7% e.e respectively.
基金
天津市自然科学基金
关键词
吡啶基
羧基
噻唑烷
手性配体
不对称硅
氢化
pyridyl)-4-carboxy-1
3-thiazolidine
chiral ligand
asymmetric hydrosilation
acetophenone
