摘要
目的:系统评价鱼腥草注射液雾化吸入治疗肺炎的疗效与安全性。方法:电子检索Medline、EMbase、Cochrane图书馆临床对照试验资料库及CBM和CNKI等数据库,收集鱼腥草注射液雾化吸入作为辅助治疗与空白或其它药物雾化吸入治疗肺炎的随机和半随机对照试验;对符合纳入标准的临床研究进行质量评价和Meta分析。结果:共纳入6个中文文献研究。所有研究均未描述具体的随机方法,均未说明是否实施了分配隐藏和采用盲法及进行随访,Juni评分均为C级。Meta分析结果显示,与对照组比较,鱼腥草注射液雾化吸入在提高肺炎临床总有效率方面显示出较好的疗效。未检索到评价鱼腥草注射液雾化吸入安全性方面的研究。结论:由于鱼腥草注射液雾化吸入治疗肺炎的临床研究质量普遍较低,且缺乏安全性研究资料,因此对鱼腥草注射液雾化吸入治疗肺炎的有效性和安全性尚不能得出肯定的结论,有必要设计良好的随机双盲对照研究进行论证。
OBJECTIVE： To evaluate the effectiveness and safety of an aerosol inhalation of Sodium Houttuyfonate injection in accessory treatment of pneumonia. METHODS： Biomedical databases, including Medline, EMbase, The Cochrane Central Register of Controlled Trials, CBM-disk and CNKI were searched. Randomized controlled trials （RCTs） and quasi- RCTs that compare aerosol inhalation of Sodium Houttuyfonate injection with placebo or other aerosol inhalation regimens were collected. A critical quality assessment and Meta-analysis were performed for included studies. RESULTS： Six RCTs were included and all of them were carried out in China. None of the trials described the method of randomization, allocation concealment, blind, and follow- up. With Junci scales, 6 trials scored C degree. Compared with the control group, aerosol inhalation of Sodium Houttuyfonate injection showed significantly higher total improvement rate. We didn＇ t find any RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation. CONCLUSION： Because of the low quality of RCTs on Sodium Houttuyfonate injection aerosol inhalation for pneumonia and the lack of RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation, no reliable conclusion can be drawn from our Meta-analysis about its efficacy and safety. Well - designed RCTs are urgently needed to evaluate the value and safety of aerosol inhalation of Sodium Houttuy- fonate injection in treating pneumonia.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第21期1652-1654,共3页
China Pharmacy
关键词
鱼腥草注射液
雾化吸入
肺炎
系统评价
Sodium Houttuyfonate injection
Aerosol inhalation
Pneumonia
Systematic review
