摘要
以间硝基苯甲醛、4-甲氧基苯甲醛、3,4,5-三甲氧基苯甲醛和乙酰丙酸乙酯为原料,经过Stobbe缩合、环合两步反应合成了化合物4-(3-硝基苯甲基)-5-亚甲基-2(5H)-呋喃、4-(4-甲氧基苯甲基)-5-亚甲基-2(5H)-呋喃和4-(3,4,5-三甲氧基苯甲基)-5-亚甲基-2(5H)-呋喃。同时观察了合成的这3种化合物对大肠杆菌和金黄色葡萄球菌的抑菌活性。结果表明,合成的这3种化合物对2种病原菌具有较好的抑菌效果。
4- （ 3-nitrobenzyl）-5-methylene-2 （ 5 H ） - furanone, 4-（ 4-met hoxybenzyl）-5-met hylene -2 （ 5 H ）- furanone and 4-（3,4, 5-trimethoxybenzyl）-5-methylene-2 （5H）-furanone were synthesized from 3-nitro-benzaldehyde,4-methoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and ethyllevulinate by Stobbe condensation and cyclization. Antibacterial activities of the three synthesized compounds against Escherichia coli and Staphylococcus aureus were observed. The results showed that the three compounds had good inhibitory activities.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2008年第7期626-628,共3页
Chinese Veterinary Science
关键词
原白头翁素衍生物
合成
抑菌活性
protoanemonin-derivate
synthesis
antibacterial activity
