4Lodder MC, Van Pelt PA, Lems WF, et al. Effects of high dose Ⅳ pamidronate on disease activity and bone metabolism in patients with active RA : a randomized, double - blind, placebo - controlled trial [J]. J Rheumatol, 2003, 30: 2080- 2081.
5Fieisch H, Russell RGG, Straumann F. Effect of pyrophosphate on hydroxyapatite and its complications in calcium homeostasis [ J ]. Nature, 1966, 212 : 901 -903.
6Graham R, Russell G. Bisphosphonates: mode of action and pharmacology[JJ. Pediatrics, 2007, 119:150 - 162.
7Lambrinoudaki I, Chritodoulakos G. Bisphosphonates [ J ]. Ann N Y Acad Sci, 2006, 1092:397-402.
9Maccagno A, Di Giorgio E, Roldan EJ, et al. Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis[ J]. Scand J Rheumatol, 1994, 23 : 211 - 214.
7Sharma A,Davis CB,Tobia LA, et al. Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4[J]. J Pharmacol Exp Ther, 2000, 293(1):33.
8Martin J, Glennie and Peter W M Johnson. Clinical trials of antibody therapy[J]. Immunology Today, 2000, 21(8):403.?A?A?A
9Salomon B, Bluestone J A. Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation[J]. Annual Review of Immunology, 2001, 19(4) :225.
10Emilia Quattrocchi, Margaret J. Dallman and Marc Feldmann. Adenovirus-Mediated Gene Transfer of CTLA-4Ig Fusion Protein in the Suppression of Experimental Autoimmune Arthritis [J]. Arthritis & Rheumatism, 2000, 43 (8): 1688.
6Raven E E, Haverkamp D, Sierevelt I N, et al. Construct validity and reliability of the disability of arm, shoulder and hand questionnaire for upper extremity complaints in rheumatoid arthritis [ J ]. J Rheumatol, 2008, 35 (12) : 2334.
7Suzuki Y, Wakabayashi T, Saito E, et al. Benefits and risks of glucocorticoid therapy for the treatment of rheumatoid arthritis and management of glucocorticoid-induced osteoporosis [ J ]. Clin Calcium, 2009, 19(3) : 404.
8Schett G, Smolen J S. New insights in the mechanism of bone loss in arthritis[J]. Curr Pharm Des, 2005, 11(23) : 3039.
9Castro-Rueda H, Kavanaugh A. Biologic therapy for early rheumatoid arthritis: the latest evidence [ J ]. Curr Opin Rheumatol, 2008, 20(3) : 314.