摘要
通过亲代雌性小鼠在一定时期内自由饮用200mg/L含氟水,使母鼠血氟浓度增高.借助组织形态学方法和放射免疫分析法观察母鼠受高氟因素作用对子代甲状腺形态、功能以及对胚胎甲状腺发生过程的影响.结果表明:母鼠受孕后开始受氟化物作用,其胎(仔)鼠血甲状腺素(T_4)水平和甲状腺滤泡细胞增高度(H)均显著高于正常对照组;亲代母鼠孕前度及孕期长期慢性氟暴露,其胎(仔)鼠在部分取材时间内其T_4和H与对照组有差别,但其变化无明显规律;氟对胚胎甲状腺的发生发育在时间上无明显延迟作用,仅使部分腺体的滤泡成熟次序发生改变.上述结果提示:母体氟暴露对子代甲状腺存在一定的不良影响.
Model mice of high blood fluoride concentration were obtained by Female mice drinking 200mg/L sodium fluoride solution freely. The effects of fluoride on morphology and function as well as ontogeny of the fetuses and neoborns' thyroid glands were studied under light microscope, transmission electron microscope (TEM) and by radioimmunoassay (RIA). The results showed that (1) short term fluoride administration of mother mice could affect the function and morphology of fetal and neoborn's thyroid glands, and result in 'hyperthyroidism'. (2) long term fluoride administration of mother mice also influenced the fetal and neoborns thyroid glands, but the changes had no markly rule. (3) fluoride didn't evidently retard the development of fetal thyroid, but changed the mature order of the follicles in some thyroid glands. The above results suggest that fluoride exposure of mother mice can induce harmful effects in fetal and neoborns thyroid glands.
关键词
氟化物
小鼠
胎儿甲状腺发生
形态
功能
Fluoride
Mice
Fetal thyroid ontogeny
Morpyology
function
