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血浆同型半胱氨酸水平变化与缺血性脑血管病的关系 被引量:10

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摘要 目的探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病及脑血管病传统危险因素之间的关系。方法选择134例急性缺血性脑血管病患者〔其中脑梗死90例,短暂性脑缺血发作(TIA)44例〕和60例对照,检测所有受试者空腹血浆Hcy水平并记录患者的脑血管病传统危险因素。分析血浆Hcy与缺血性脑血管病的相关性以及高同型半胱氨酸血症(HHcy)与传统危险因素的关系。结果缺血性脑血管病组、脑梗死组与TIA组患者血浆Hcy水平均高于对照组(P<0·05),但脑梗死组与TIA组血浆Hcy水平相比较无差异(P>0·05);按各项传统危险因素将所有受试者分别分为有危险因素组、无危险因素组,并进行两组间血浆Hcy水平比较,差异无显著性(P>0·05);但高血压合并HHcy者与高血压Hcy正常者相比,患缺血性脑血管病的危险性增大(P<0·05)。结论血浆Hcy水平升高可能是与传统危险因素无关的缺血性脑血管病的独立危险因素,HHcy可能与某些传统危险因素协同作用促进缺血性脑血管病的发生。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第13期1296-1298,共3页 Chinese Journal of Gerontology
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