摘要
目的探讨不良孕产史夫妇染色体变化的有关特点和意义。方法对2174例有自然流产、胚胎停育或生育畸形儿史的患者,进行外周血进行淋巴细胞培养,G显带染色体核型分析,并对不良孕产次数与染色体异常及性别与染色体异常的关系进行统计学分析。结果2174例患者中发现染色体核型异常142例,异常率6.53%。不同就诊原因的染色体异常检出率差异无统计学意义;不良孕产史次数与染色体异常检出率、性别与染色体异常检出率的差异均有统计学意义。结论染色体异常是导致不良孕产的重要原因之一,对有不良孕产史的患者进行染色体检查可以为临床诊疗提供有效的依据。
Objective： To investigate the relationship between the abnormal childbearing history and chromosome aberration. Methods .. Chromosomal karyotypes of 2174 patients with spontaneous abortion or embryo growth ceasing or with bearing malformation child history was analyzed by using G - banding after culture of periphery blood lymphocyte. Analysis the relationship between the fragrances of abnormal child - bearing, gender and Chrgmosomal abnormality detection rate. Results ： 142 patients with abnormal chromosomal karyotypes were detected from 2174 patients. Chromosomal abnormality detection rate of different reasons was not significant. The fragrances of abnormal child - bearing and gender＇s chromosomal abnormality detection rate had a significant difference. Conclusion ： Chromosomal abnormalities is one of the the important factors leading to the abnormal childbearing. The examination of chromosomal karyotypes can provides effective evidence for clinical diagnoses of patients with abnormal childbearing history.
出处
《中国优生与遗传杂志》
2008年第7期35-36,共2页
Chinese Journal of Birth Health & Heredity
关键词
不良孕产史
染色体异常
核型分析
细胞遗传学
Abnormal childbearing history
Chromosome abnormality
Analysis of karyotype
Cytogenetics
