摘要
目的了解杭州市不同妊娠期妇女尿碘与尿肌酐水平，为指导妊娠妇女科学补碘提供依据。方法采用酸消化砷-铈接触法检测水碘、尿碘；苦味酸法测定尿肌酐；硫代硫酸钠法测定盐碘。结果妊娠早、中、晚期妇女尿碘中位数分别为171．30μg/L、167．35μg/L、162．40μg/L，均明显低于对照组（251．90μg/L）（Z=-2．315，P=0．021；Z=-4．352，P=0．000；Z=-3．704，P=0．000）；妊娠早、中、晚期妇女尿碘值〈150μg/L比例分别占40．0％、45．1％、43．3％，其比例显著高于对照组（24．2％）（χ^2=5．551，P=0．018；χ^2=9．226，P=0．002；χ^2=7．647，P=0．006）；妊娠早、中、晚期妇女尿肌酐均值分别为1．37g／L、0．97g／L、0．81g／L，均显著低于对照组（1．68g／L）（P〈0．05），且妊娠中、晚期妇女尿肌酐水平显著低于妊娠早期（P〈0．05）。结论杭州市碘盐供应良好，妊娠妇女总体尿碘水平处于适宜范围，但随着孕龄的增加，尿碘和尿肌酐水平依次下降，妊娠中、晚期妇女更易发生碘营养不足；妊娠妇女需在食用碘盐基础上，定期进行碘营养监测，科学补碘。
Objective To evaluate the levels of urinary iodine and urinary ereatinine in pregnant women during different trimester and provide basis for scientific iodine supplement. Methods The levels of urinary iodine and water iodine were measured by speetrophotometer method. The levels of urinary ereatinine and salt iodine were measured by pierie acid method and sodium thiosulfate titrimetrie method, respectively. Results ①The urinary iodine medians during the first, second and the third trimester of pregnancy were 171.30μg/L, 167. 35 μg/L, 162. 40 μg/L, respectively, and were all significantly lower than that of non - pregnant women which was 251.90 μg/L （Z = - 2. 315, P = 0.021; Z = - 4. 352, P = 0.000, Z = -3.704, P =0. 000） ; ②The percentages of urinary iodine level lower than 150 μg/L during the first, second and third trimester of pregnancy were 40.0% , 45.1% and 43.3% , respectively, which were significantly higher than that in non - pregnant women （24.2%）（χ^2 =5.551, P=0.018; χ^2=9.226, P=0.002; χ^2 =7.647, P=0.006） ;③The means of urinary creatinine during the first, second and third trimester of pregnancy were 1.37 g/L, 0. 97 g/L, 0. 81 g/L, respectively, which were lower than that of non - pregnant women （ P 〈 0.05 ）. The mean of urinary ereatinine in the first trimester was significantly lower than that in the second and third trimester （ P 〈 0. 05）. Conclusion In areas with high iodized salt coverage, median urinary iodine of pregnant women was well within optimal range, but the levels of urinary iodine and urinary ereatinine went down in turn along with the gestational age. The women during the second and the third trimester may be prone to iodine malnutrition, so the status of pregnant women＇s iodine nutrition should be supervised regularly and foods containing iodine should be taken on the basis of iodine - adding salt intake.
出处
《中国预防医学杂志》
CAS
2008年第7期595-597,共3页
Chinese Preventive Medicine
基金
浙江省医药卫生科学研究基金项目(2007B186)
关键词
妊娠妇女
尿碘
尿肌酐
Pregnant women
Urinary iodine
Urinary creatinine
