摘要
目的比较雾化吸入布地奈德混悬液与吸入布地奈德气雾剂治疗婴幼儿哮喘的疗效。方法将80例年龄小于3岁的哮喘息儿随机分为三组，A组（20例）用雾化器吸入布地奈德混悬液；B组（30例）使用面罩型筒式贮雾罐吸入布地奈德气雾剂；对照组（30例）不用吸入激素，常规治疗。在观察期的第1、3、6、12个月复诊，比较三组的临床症状评分、哮喘急性发作及药物使用的情况。结果与对照组相比，A组和B组日间、夜间症状评分明显降低（P〈0．01），哮喘的急性发作显著减少，使用β2受体激动剂和全身激素的次数减少（P〈0．01）；而A组在观察期的第1、3、6个月的治疗效果比B组更明显（P〈0．05），两组在第12个月的治疗指标的差异无统计学意义（P〉0．05）。结论吸入布地奈德治疗可使哮喘得到长期的缓鹪；使用雾化器吸入布地奈德混悬液，可以更早、更好地减轻哮喘症状，是婴幼儿哮喘的首选吸入方式。
Objective To evaluate the efficacy of inhalation of budesonide bitween suspension and aerosol in the treatment of infant asthma. Methods 80 patients less than 3 years old were divided in three groups randomly,in group A the patients received budesonide suspension inhalation therapy, in group B the patients received budesonide aeroso inhalation therapy, in group C the patients received route treament. The patients were followed 1,3,6,12 months after teeament,syrnptom assessment scores, acute episode of asthma and administration of medication were compared beteen two groups. Results Compared with group C, symptom assessment scores became lower （ P 〈 0.01 ） ,acute episode of asthma reduced and use of receptor 132 receptor agonist and steroid reduced in group A and B （P〈 0.01 ）;after i, 3,6 months, the indicators observed in group A was better than in group B（P 〈 0.05）, but there was no difference between two group after 12 months（P 〉0.05）. Conclusion Budesonide inhalaton is effective in the treatment of asthma, in patients with infant asthma, budesonide suspension aerosol inhalation should be the first choice of treatment.
出处
《中国基层医药》
CAS
2008年第6期983-985,共3页
Chinese Journal of Primary Medicine and Pharmacy
