摘要
目的研究感染性心内膜炎(IE)的流行病学、致病微生物、治疗及预后。方法调查中国人民解放军总医院近10年心外科65例IE患者的病例资料,并加以回顾性分析。结果65例IE患者,男女比例2.1∶1,平均年龄(41.5±13.4)岁,细菌培养阳性率63.08%,手术率81.5%,其中主动脉瓣置换术占58.18%,住院死亡率9.23%。应用抗菌药物以青霉素类、头孢菌素类、喹诺酮类为主,基本合理。结论IE患者多患有基础心脏病和退行性瓣膜病,早期诊断,适时手术和内、外科联合治疗是治疗成功的关键。
Objective To investigate the epidemiology, pathogenic microorganism, management and prognosis of infective endocarditis （ IE ）. Methods This was a retrospective study. Clinical data of 65 infective endocarditis patients who were in cardiac surgery during the last 10 years in Chinese PLA General Hospital were analyzed. Results Among the 65 patients with IE, the male gender predominated with a sex ratio of 2.1：1 and the mean age of the global population was （41.5 ± 13.4） years. Bacterial cultures were positive in 63.08% of patients, 81.5% patients accepted surgery and aortic valve replacement possessed 58. 18%. The in - hospital mortality rate was 9.23 %. Penicillins, cephalosporins, and quinolones took the lead places in the usage of antibacterials. The inpatient use of antibacterials in IE patients was basically rational. Conclusion Most of the patients in this investigation suffered cardiac diseases. Early diagnosis and prompt treatment both medical and surgical interventions can improve the outcome of IE patients.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2008年第4期358-360,共3页
The Chinese Journal of Clinical Pharmacology
