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Bmi-1在喉癌组织中的表达及相关性 被引量：2

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摘要 目的探讨Bmi-1在喉癌组织和癌旁组织中的表达及其与临床病理特征的关系。方法收集10例喉癌患者的癌组织及癌旁组织,采用RT-PCR方法检测其Bmi-1mRNA表达情况;采用SP免疫组织化学法对46例喉癌患者手术标本石蜡切片进行染色,检测Bmi-1蛋白的表达,并分析Bmi-1与临床病理特征的相关性。结果喉癌组织中Bmi-1mRNA表达水平明显高于癌旁对照组织。Bmi-1蛋白在喉癌中的阳性表达率为67.39%。Bmi-1的表达与喉癌的临床分期、淋巴结转移、肿瘤分化程度密切相关(P<0.05),而与患者的性别、年龄、临床分型等无关。结论Bmi-1在喉癌组织中表达状态与喉癌的生长和转移关系密切,可以作为反映喉癌生物学行为的有效指标。
作者 于丹 金春顺 高丽芳 文莲姬
机构地区 吉林大学第二医院耳鼻咽喉头颈外科 吉林大学基础医学院病理生理教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第14期1365-1367,共3页 Chinese Journal of Gerontology
基金 吉林省科技厅重大社会发展项目(编号:20060416) 吉林省科技厅应用基础项目(编号:200705194)
关键词 喉癌 Bmi.1 RT—PCR 免疫组织化学染色
分类号 R739.65 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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共引文献10

同被引文献14

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引证文献2

二级引证文献3

中国老年学杂志
2008年 第14期

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