摘要
目的分析研究少精子症、死精子症、无精子症患者的遗传缺陷与男性不育的关系,并探讨该类患者在接受辅助生殖技术治疗前进行细胞遗传学检查的重要性。方法采用外周血淋巴细胞染色体培养技术进行染色体核型分析。结果268例患者中共检出异常核型65例,异常率24.3%(65/268);其中性染色体数目异常58例,占89.3%;染色体结构异常3例,占4.6%;大Y 3例,占4.6%;性反转46,XX 1例,占1.5%。160例正常生育男性的染色体核型分析,共检出异常核型2例,其中大Y 1例,小Y 1例,异常率1.25%(2/160)。结论染色体核型异常时引起男性不育症的重要因素之一,这类不育患者在接受辅助生殖助孕技术前进行染色体核型分析,避免将各种遗传缺陷传递给下一代,对优生优育起着重要作用。
Objective： Analysis of oligospermia, dead azoospermia azoospermia patients with genetic defects and male infertility, and explore such patiens in the assisted reproductive technology treatment for cytogenetics the importance of inspection. Methods： U- sing peripheral blood lymphocyte culture technology for chromosome karyotype analysis. Results： 268 patients were detected abnormal karyotype, 65cases of abnormal rate of 24. 3% （65/268） ; ok with abnormal chromosome number 58, accounting for 89. 3% ; Abnormal chromosome structure of three cases, accounting for 4. 6% ; Big Y chromosome 3 cases, accounting for 4. 6% ; reversal one cases, accounting for 1.5%. 160 cases of male reproductive normal karyotype analysis wer detected abnormal karyotype two cases, in which the majority of Y chromosome 1, small Y chromosome 1 cases. The abnormal rate of 1.25%. Conclusion： Karyotypic abnormalities cause of male infertility is one of the important factors, such infertility patients in assisted reproductive technology treatment before karyotype analysis, avoid genetic defects on to the next generation, to cure an important role to play.
出处
《中国优生与遗传杂志》
2008年第8期63-64,共2页
Chinese Journal of Birth Health & Heredity
关键词
男性不育
少精子
死精子
无精子
染色体核型
Male infertility
Oligozoospermia, Dead sperm, No sperm
Karyotype
