摘要
目的研究多潘立酮对功能性消化不良（FD）患者的治疗效果，进一步探讨其治疗机制。方法采用自身对照的研究方法，随机选取31例FD患者，停止应用影响胃酸分泌及胃动力的药物1周后，给予症状评分，并进行胃排空检测和餐前、餐后胃电图的检测；口服多潘立酮2周后，再次进行症状评分，并进行胃排空和餐前、餐后胃电图检测。结果FD患者口服多潘立酮2周后，上腹痛、腹胀、早饱、嗳气等临床症状明显改善，治疗前症状积分48．20±21．71，治疗后症状积分19．00±11．03，治疗前后比较，差异有统计学意义（P〈0．01）；FD患者治疗前后胃排空率检测比较：2、5h胃总排空率均明显增加（17％与57％，56％与96％，均P〈0．01）；FD患者治疗后与治疗前胃电参数指标进行比较：①主频：实验组治疗前餐前主频值（2、57±0．60）cpm，餐后主频值（2．70±0．53）cpm；治疗后餐前主频值（3、00±0．26）cpm，餐后主频值（3．01±0．27）cpm；FD患者口服多潘立酮两周后主频与治疗前比较，餐前之间相比差异有统计学意义（P〈0．05），餐后之间相比差异亦有统计学意义（P〈0、05）。②主功率：实验组治疗前餐前主功率值（55．36±8．46）μV，餐后（72．30±10．35）μV；实验组治疗后餐前主功率值（75．06±13、13）μV，餐后（112．27±17、27）μV，主功率显著增加（P〈0．05）；③正常胃电慢波百分比显著增多（54．8％-93、4％）（P〈0、01）；胃动过缓百分比显著减少（19、4％→3．2％）（P〈0、01）；胃动过速百分比显著减少（25．8％→3．2％）（P〈0．01）。结论多潘立酮可显著改善FD患者的上腹痛、腹胀、早饱、嗳气等主要症状，增强胃电活动及胃排空，增加胃电图的主频及主功率，使紊乱的胃电节律趋于正常。
Objective To investigate the curative effect of Domperidone in treating functional dyspepsia （ FD） ,to observe the changes of electrogastrogram in these patients both before and after meal,and to investigate the mechanism of Domperidone for treating FD. Methods Self-control methods were used for study. 31 patients with functional dyspepsia selected randomly committed to symptom score after they stopped taking medicine that affected gastric acid secretion for a week. Then the changes of electrogastrogram were detected before meal with emptying of stomach. After patients took orally Domperidone for two weeks, electrogastrogram and symptoms score were detected again under the same condition. Results 2 weeks after treatment with oral Domperidone, the patients had significant improvement in upper abdominal pain, abdominal distension and belching. The symptom score changed from 48.20±21.71 to 19.00 ± 11.03（P 〈 0.01）. The gastric emptying rate for 2 hours and 5 hours increased significantly after treatment （ P 〈 0. O1 ）. As for the gastric electrical activity parameter： ①basic frequency changed from （ 2.57± 0.60） cpm to （ 3.00± 0.26） cpm before meal, and changed from （ 2.70 ±0.53 ） cpm to （ 3.01 ±0.27 ） cpm（ P 〈0.05 for each）.② main power, experimental group＇s main power changed from （ 55.36 ± 8.46 ） μV to （75.06 ± 13.13 ） μN before treatment and meal,and changed from （72.30 ± 10.35 ） μN to （ 112.27 ± 17.27 ） μV after meal and treatment （ P 〈 0.05 ）. ③ Slow wave of gastric electrical activity （ N% ） increased significantly （ 54.8% →93.4% ） （ P 〈 0.01 ）. Bradygastria （ B% ） reduced significantly （ 19.4% →3.2% ） （ P 〈 0.01 ）. Tachygastria （ T% ） reduced significantly （ 25.8% →3.2% ） （ P 〈 0.01 ）. Conclusion Domperidone has significant effect in improving some major symptoms like upper abdominal pain, abdominal distension and belching, and may strengthen gastric emptying,increase basic frequency and main power of electrogastrogram,so to convert the disturbed gastric electrical activity to normal.
出处
《中国综合临床》
北大核心
2008年第7期685-688,共4页
Clinical Medicine of China
关键词
多潘立酮
功能性消化不良
胃电图
Domperidone
Functional dyspepsia
Electrogastrogram
