摘要
目的:通过观察各级支气管的病理变化,探讨射频消融对支气管的影响,为其临床应用提供依据.方法:6只健康家猪分为2组,进行经皮穿刺正常肺组织射频消融,分别于消融后3 d和28 d各宰杀3只,观察消融区形态及大小和各级支气管的病理表现.结果:28 d时活检消融损伤区最大直径明显小于3 d时(t=2.853,P=0.017).随着支气管腔的变小,射频对支气管的损伤加重;对主支气管、二级支气管的损伤较轻.主支气管、二级支气管消融后28 d恢复较好.二级以上支气管未出现支气管瘘.结论:射频消融对于二级以上支气管损伤较轻,且可于28d基本恢复正常,是一种相对安全的肺部肿瘤微创治疗方法.
AIM ： To observe the pathological changes of different grades of bronchus after radiofrequency ablation and to evaluate the effects of radiofrequency ablation on bronchus. METHODS： The subcutaneous radiofrequency ablations on normal pulmonary tissues were performed on 6 healthy domestic swine. Three swine were killed 3 days（ 3 d group） after the ablation and the other 3 were killed 28 days （28 d group） after the ablation. The shapes and sizes of ablation area were measured and the pathological morphology of different grades of bronchus was evaluated. RESULTS ： The maximal diameter of the thermal damage in 28 d group was significantly smaller than that in 3 d group（ t = 2. 853, P =0.017）. The damage of radiofrequency ablation to the bronchus was aggravated with the shrinkage of the bronchus ; the damages to the main bronchus and the second grade bronchus were relatively slight. The better recovery of larger bronchus was found in 28 d group. There was no bronchial fistulas on the larger bronchus. CONCLUSION： The damages of radiofrequency ablation on larger bronchus are mild which could recover 28 days after ablation. The subcutaneous radiofrequency ablation is a relatively safe, minimal invasive therapy for the patients with pulmonary tumors.
出处
《第四军医大学学报》
北大核心
2008年第14期1279-1281,共3页
Journal of the Fourth Military Medical University
